Herpes Simplex Virus

Division of Pediatric Infectious Disease, University of Virginia, Charlottesville, Virginia, United States
Pediatrics in Review (Impact Factor: 0.82). 04/2004; 25(3):86-93. DOI: 10.1542/pir.25-3-86
Source: PubMed


HSV infections vary in presentation and management among neonates, children, and adolescents. Early consideration and treatment for neonatal disease is essential. Clinical diagnosis alone usually is adequate for most of the mucocutaneous HSV presentations in childhood and adolescence. The case of antiviral therapy administration has improved, although delays in diagnosis and the overwhelming clinical manifestations of invasive HSV disease make this a devastating illness, particularly in the newborn and immunocompromised patient.

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Available from: Linda Ann Waggoner-Fountain, Apr 08, 2014
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    ABSTRACT: Several viruses are able to infect eyes and ocular adnexa of vertebrates. Considering the variety of cells and tissues comprising eyes and adnexa, viruses have multiple opportunities to colonize them and to induce a pathologic effect. This also varies depending on the animal species, age, immune status, virus species and type. Viruses may target conjunctival, glandular, corneal and/or retinal epithelium, endothelium, myocytes and pericytes, retinal and optic nerve neurons, fibers and glial cells, and lymphocytes, macrophages and dendritic cells of lymphoid follicles. Cell injury can be induced by direct cytopathic effect or via inflammatory mediator release and/or protelytic enzymes released by inflammatory cells or the injury may result from the intraparietal vascular deposition of antigen antibody complexes and following complement activation. In fetuses and youngsters some agents are able to induce various degrees of ocular dysplasia. Immunodeficiency viruses favor the colonization and growth of other agents such as other viruses, bacteria, protozoa and mycetes. Leukemia oncornaviruses can cause neoplastic lymphocytic infiltration of eyes and adnexa. This review includes viruses able to affect multiple species of vertebrates, and others specific to ruminants, horses, pigs, marsupials, dogs, cats, minks, rabbits, rats, birds and fish. Herpesvirus, arterivirus, orbivirus, paramyxovirus, morbillivirus, nodavirus, pestivirus, asfivirus, orthomyxovirus, retrovirus, lentivirus, adenovirus, calicivirus, coronavirus, reovirus and prions are discusses. Zoonotic agents include influenza orthomyxoviruses, Newcastle disease paramyxovirus, rabies rhabdovirus, transmissible bovine spongiform encephalopathy prion, simian immunodeficiency lentivirus, cercopithecine herpesvirus 1 and perhaps Borna disease virus. Anthropozoonoses include human measles morbillivirus and herpes simplex virus.

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