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Anti-diarrheal and spasmolytic activities and acute toxicity study of Soonkijangquebo, a herbal anti-diarrheal formula

Inha University, Chemulpo, Incheon, South Korea
Journal of Ethnopharmacology (Impact Factor: 3). 04/2004; 91(1):75-80. DOI: 10.1016/j.jep.2003.11.019
Source: PubMed

ABSTRACT The anti-diarrheal and spasmolytic activities of Soonkijangquebo (SKJQB), a Korean herbal anti-diarrheal formulation, were subjected to pharmacological evaluation. SKJQB, at a dose of 50-200 mg/kg, inhibited castor oil-induced diarrhea in mice. The median effective dose (ED50) for the anti-diarrheal effect was 93 mg/kg. In isolated rabbit jejunum preparations, SKJQB produced a spasmolytic effect by the relaxation of spontaneous contractions in a dose-dependent manner. The median effective concentration (EC50) for the spasmolytic effect was 3.6 mg/ml. In isolated guinea pig ileum preparations, SKJQB also produced a spasmolytic effect by reduction of acetylcholine-induced contractions. When tested against calcium channel blockade in rabbit jejunum, SKJQB caused a dose-dependent rightward shift in the Ca2+ dose-response curves, similar to that produced by verapamil, a well-known calcium antagonist. In an acute toxicity study in Sprague-Dawley rats, the median lethal dose (LD50) of SKJQB was greater than 2000 mg/kg, and no pathological changes were noticed in macroscopic examination by necropsy of rats treated with SKJQB. Thus, SKJQB may be safely used as a spasmolytic as well as an anti-diarrheal agent.

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    • "The people of India have a very long-standing tradition in the use of natural medicines and the local practices are still quite common in the treatment of diseases (Srinivasan et al., 2001; Harsha et al., 2002). The assessment of plants used in conventional medicines is anticipated to make available new antimicrobial agents (Otshudi et al., 2000b; Ryu et al., 2004). Thus, present study is aimed to investigate and establish the antidiarrhoeal potential of plant extracts used in folk medicine. "
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    • "La experimentación se realizó en AR, YAC e IAC. Ryu et al., 2004. (Korea). "
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    Journal of Ethnopharmacology 11/2005; 101(1-3):197-203. DOI:10.1016/j.jep.2005.04.016
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