Pathologic quiz case: myxoid tibial lesion in a 31-year-old man. Low-grade myxofibrosarcoma

Department of Pathology, The University of Texas Southwestern Medical Center, Dallas 75390-9073, USA.
Archives of pathology & laboratory medicine (Impact Factor: 2.84). 05/2004; 128(4):e65-6.
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    • "Other sites for myxofibrosarcomas included head and neck region, retroperitoneum, pelvis and heart [3,4]. However, a primary myxofibrosarcoma with bone invasion was rarely reported [5-11]. In addition, the peak age incidence of myxofibrosarcomas was in the fifth to seventh decades with a slight male predominance [2,12]. "
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    ABSTRACT: Myxofibrosarcoma is a myxoid variant of malignant fibrous histiocytoma that most commonly involves the extremities of elderly people. However, a primary myxofibrosarcoma with bone invasion in young adults is extremely rare. Herein, we report the case of a 31-year-old male with a gradually enlarging left thigh mass, who had a history of left femur fracture and received an open reduction and internal fixation with titanium alloy plates and screws 33 months previously. Imaging investigations revealed an irregularly shaped soft tissue mass around the left femur shaft and a partial bone defect in the middle one-third of the left femur. Pathological examination of the resected specimen showed a multi-nodular appearance, abundant myxoid matrix and elongated curvilinear capillaries. Immunohistochemical studies revealed that the tumor cells was positive for VIM and MDM2, and was negative for CK, MSA, SMA, DES, S-100 and CD34. Labeling index of Ki-67 was 25%. Based on the morphological finding and immunostaining, it was diagnosed as a low-grade myxofibrosarcoma. The clinical and imaging examinations did not reveal the evidence of a primary cancer elsewhere, and the patient had no personal or family history of malignancy. To our knowledge, this is the first case of a primary myxofibrosarcoma developed following a fracture and metal implantation in young adults. Virtual slides The virtual slide(s) for this article can be found here:
    Diagnostic Pathology 01/2014; 9(1):6. DOI:10.1186/1746-1596-9-6 · 2.60 Impact Factor

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