Article

Agranulocytosis induced by vancomycin in an ESRD patient on CAPD.

Division of Nephrology, Department of Internal Medicine, Konkuk University College of Medicine, Seoul, Korea.
The Korean Journal of Internal Medicine 04/2004; 19(1):58-61.
Source: PubMed

ABSTRACT Agranulocytosis is a rare adverse effect associated with prolonged vancomycin therapy, and is potentially serious, especially in end stage renal disease (ESRD) patients. We describe a continuous ambulatory peritoneal dialysis (CAPD) patient that developed vancomycin-induced agranulocytosis during treatment for methicillin-resistant Staphylococcus aureus (MRSA)-associated external cuff infection and pneumonia. The agranulocytosis was rapidly resolved by granulocyte colony-stimulating factor (G-CSF) therapy and by the discontinuation of vancomycin.

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Keywords

CAPD
 
continuous ambulatory peritoneal dialysis
 
end stage renal disease
 
granulocyte colony-stimulating factor
 
methicillin-resistant Staphylococcus aureus
 
MRSA)-associated external cuff infection
 
rare adverse effect
 
vancomycin therapy
 

Young-Il Jo