Excess electron transport through DNA: a single electron repairs more than one UV-induced lesion.
Department of Chemistry, University of Basel, St. Johanns-Ring 19, 4056 Basel, Switzerland.Angewandte Chemie International Edition (Impact Factor: 13.73). 04/2004; 43(14):1848-51. DOI:10.1002/anie.200353264
- Angewandte Chemie International Edition 09/2006; 45(32):5376-80. · 13.73 Impact Factor
- Angewandte Chemie International Edition 01/2006; 45(2):318-21. · 13.73 Impact Factor
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ABSTRACT: Electron transfer in DNA has been intensively studied to elucidate its biological roles and for applications in bottom-up DNA nanotechnology. Recently, mechanisms of electron transfer to DNA have been investigated; however, most of the systems designed are intramolecular. Here, we synthesized pyrene-conjugated pyrrole-imidazole polyamides (PPIs) to achieve sequence-specific electron injection into DNA in an intermolecular fashion. Electron injection from PPIs into DNA was detected using 5-bromouracil as an electron acceptor. Twelve different 5-bromouracil-containing oligomers were synthesized to examine the electron-injection ability of PPI. Product analysis demonstrated that the electron transfer from PPIs was localized in a range of 8 bp from the binding site of the PPIs. These results demonstrate that PPIs can be a useful tool for sequence-specific electron injection.Nucleic Acids Research 02/2013; · 8.28 Impact Factor
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