Large Bowel Obstruction Heralding Churg-Strauss Syndrome [1]

Università degli studi di Parma, Parma, Emilia-Romagna, Italy
The American Journal of Gastroenterology (Impact Factor: 10.76). 04/2004; 99(3):562-3. DOI: 10.1111/j.1572-0241.2004.04105.x
Source: PubMed


The American Journal of Gastroenterology is published by Nature Publishing Group (NPG) on behalf of the American College of Gastroenterology (ACG). Ranked the #1 clinical journal covering gastroenterology and hepatology*, The American Journal of Gastroenterology (AJG) provides practical and professional support for clinicians dealing with the gastroenterological disorders seen most often in patients. Published with practicing clinicians in mind, the journal aims to be easily accessible, organizing its content by topic, both online and in print., *2007 Journal Citation Report (Thomson Reuters, 2008)

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    ABSTRACT: Churg-Strauss syndrome is a rare diffuse vasculitis that is almost invariably accompanied by severe asthma. Although overall prognosis is good, and treatment with prednisone alone or in combination with immunosuppressive drugs is usually successful, severe asthma typically persists. Diffuse organ involvement of Churg-Strauss syndrome, especially cardiovascular and rare involvement of the CNS and renal system, suggests a poorer prognosis than usual, and can be fatal. The cause of Churg-Strauss syndrome is unknown, but its characteristic histological findings and association with asthma distinguish it from other vasculitides. Controversy surrounds the use of asthma drugs-especially antileukotrienes--and development of the disorder. We review the epidemiological evidence for an association of drug treatment with Churg-Strauss syndrome, the diverse diagnostic and pathological criteria for this syndrome, and treatment options.
    The Lancet 03/2003; 361(9357):587-94. DOI:10.1016/S0140-6736(03)12518-4 · 45.22 Impact Factor
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    ABSTRACT: To explore the association between HLA alleles and Churg-Strauss syndrome (CSS), and to investigate the potential influence of HLA alleles on the clinical spectrum of the disease. Low-resolution genotyping of HLA-A, HLA-B, and HLA-DR loci and genotyping of TNFA -238A/G and TNFA -308A/G single-nucleotide polymorphisms were performed in 48 consecutive CSS patients and 350 healthy controls. The frequency of the HLA-DRB1*07 allele was higher in the CSS patients than in controls (27.1% versus 13.3%; chi(2) = 12.64, P = 0.0003, corrected P [P(corr)] = 0.0042, odds ratio [OR] 2.42, 95% confidence interval [95% CI] 1.47-3.99). The HLA-DRB4 gene, present in subjects carrying either HLA-DRB1*04, HLA-DRB1*07, or HLA-DRB1*09 alleles, was also far more frequent in patients than in controls (38.5% versus 20.1%; chi(2) = 16.46, P = 0.000058, P(corr) = 0.000232, OR 2.49, 95% CI 1.58-3.09). Conversely, the frequency of the HLA-DRB3 gene was lower in patients than in controls (35.4% versus 50.4%; chi(2) = 7.62, P = 0.0057, P(corr) = 0.0228, OR 0.54, 95% CI 0.35-0.84). CSS has 2 major clinical subsets, antineutrophil cytoplasmic antibody (ANCA)-positive, with features of small-vessel vasculitis, and ANCA-negative, in which organ damage is mainly mediated by tissue eosinophilic infiltration; analysis of HLA-DRB4 in patients categorized by different numbers of vasculitic manifestations (purpura, alveolar hemorrhage, mononeuritis multiplex, rapidly progressive glomerulonephritis, and constitutional symptoms) showed that its frequency strongly correlated with the number of vasculitis symptoms (P for trend = 0.001). These findings indicate that HLA-DRB4 is a genetic risk factor for the development of CSS and increases the likelihood of development of vasculitic manifestations of the disease.
    Arthritis & Rheumatology 09/2007; 56(9):3159-66. DOI:10.1002/art.22834 · 7.76 Impact Factor
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    ABSTRACT: A 51-year-old Caucasian man was hospitalized because of myalgia and fever. He had been suffering from chronic rhinitis since the age of 18 years and from asthma since the age of 45 years. Three months before hospitalization, he had received an influenza vaccine. On admission, he also complained of fatigue and paresthesias involving the lower limbs, and reported the recent onset of palpable purpura at both legs (Figure 1a). Laboratory tests are summarized in Table 1. The patient's HLA-DRB1 genotype was positive for *04-*07 alleles, both belonging to the HLA-DRB4 gene. Chest computed tomography (CT) scan was normal, whereas head CT showed diffuse sinusitis (Figures 1c and d). Electroneurography disclosed sensorimotor polyneuropathy with signs of axonal damage affecting the right peroneal and left sural nerves. A biopsy of the purpuric lesions was performed, and histology showed leukocytoclastic vasculitis (Figure 1b). As an antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis was suspected and urinary abnormalities persisted, renal biopsy was performed. On light microscopy (Figure 2), the biopsy specimen included 24 glomeruli, 3 of which were obsolescent. Segmental necrosis was found in 30% of the glomeruli, whereas four showed extracapillary proliferation. The tubulointerstitium, arterioles, and venules were normal, with no eosinophilic infiltration. Immunofluorescence showed no immune deposits. Churg-Strauss syndrome (CSS) was diagnosed on the basis of histological findings showing vasculitis and the presence of asthma, eosinophilia, sinusitis, and polyneuropathy. Prednisone therapy (initial dose 1 mg/kg/day) induced rapid symptom remission, normalization of the eosinophil count, and urinary abnormalities. Prednisone was stopped 9 months later but was resumed soon after withdrawal because of relapsing asthma.
    Kidney International 07/2009; 76(9):1006-11. DOI:10.1038/ki.2009.210 · 8.56 Impact Factor
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