Effect of supplemental vitamin E for the prevention and treatment of cardiovascular disease.

Southern California Evidence-Based Practice Center, Rand Corporation, Santa Monica, California, USA.
Journal of General Internal Medicine (Impact Factor: 3.42). 05/2004; 19(4):380-9. DOI: 10.1111/j.1525-1497.2004.30090.x
Source: PubMed

ABSTRACT To evaluate and synthesize the evidence on the effect of supplements of vitamin E on the prevention and treatment of cardiovascular disease.
Systematic review of placebo-controlled randomized controlled trials; meta-analysis where justified.
Eighty-four eligible trials were identified. For the outcomes of all-cause mortality, cardiovascular mortality, fatal or nonfatal myocardial infarction, and blood lipids, neither supplements of vitamin E alone nor vitamin E given with other agents yielded a statistically significant beneficial or adverse pooled relative risk (for example, pooled relative risk of vitamin E alone = 0.96 [95% confidence interval (CI), 0.84 to 1.10]; 0.97 [95% CI, 0.80 to 1.90]; and 0.72 [95% CI, 0.51 to 1.02] for all-cause mortality, cardiovascular mortality, and nonfatal myocardial infarction, respectively.
There is good evidence that vitamin E supplementation does not beneficially or adversely affect cardiovascular outcomes.

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    ABSTRACT: The Australian Government acting through the Bureau of Rural Sciences has exercised due care and skill in the preparation and compilation of the information and data set out in this publication. Notwithstanding, the Bureau of Rural Sciences, its employees and advisers disclaim all liability, including liability for negligence, for any loss, damage, injury, expense or cost incurred by any person as a result of accessing, using or relying upon any of the information or data set out in this publication to the maximum extent permitted by law.

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