Sinonasal malignancies.

Department of Otolaryngology-Head and Neck Surgery, Massachusetts Eye and Ear Infirmary, Boston 02114, USA.
Otolaryngologic Clinics of North America (Impact Factor: 1.34). 05/2004; 37(2):473-87. DOI: 10.1016/S0030-6665(03)00159-2
Source: PubMed

ABSTRACT Sinonasal malignancies are highly heterogeneous lesions that are challenging to diagnose, treat, and follow clinically. Outcomes remain relatively poor and are associated with late diagnosis, difficult surgical anatomy, and a lack of effective adjuvant modalities of treatment. New multimodal treatment protocols addressed to specific tumor entities are being assessed with promising results. Because of the relative rarity of these lesions, however, progress is slow. The best therapeutic outcomes are achieved in the setting of early diagnosis combined with a meticulous, comprehensive, multidisciplinary approach to the management of these complex tumors.

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    ABSTRACT: Sinonasal malignancies are said to be a highly heterogeneous group of cancers, accounting for less than 1 % of all cancers and less than 3 % of all upper aerodigestive tract tumors. Originating from any histologic components of the sinonasal cavity, the histopathology of these tumors is diverse. Accordingly, treatment options vary, surgery being the mainstay in most of them. Recurrence rates differs with each histological type of tumor, dependent on various factors. In this article, we have tried to identify the prevalent characteristics of sinonasal malignancies and to outline the prognostic factors affecting the outcome. It is a retrospective study design with a total number of 102 patients. Patients diagnosed with sinonasal malignancies were included and any patient previously operated outside our institute or having received prior radiation or chemotherapy were excluded. The patients were selected over a period of 10 years, from 2000 to 2010. Data was analyzed using SPSS 17. Majority of the sinonasal tumors were squamous cell carcinomas involving the maxillary sinus. Locoregional recurrence was found to be more frequent in patients with positive neck nodes on final histopathology. Sinonasal malignancies are mostly squamous cell in variety and recurrence of these rare entities is dependent on the histological variety and the presence of positive neck nodes.
    Indian Journal of Otolaryngology and Head & Neck Surgery 07/2013; 65(1). DOI:10.1007/s12070-013-0650-x · 0.05 Impact Factor
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    ABSTRACT: CT is the initial imaging of choice for patients with symptoms of inflammatory paranasal sinus disease. N The aim of imaging the paranasal sinuses is to confirm diagnosis, localize the disease, characterize the extent of pathology and describe any anatomical variations. N An understanding of the anatomy is important for surgical planning and some normal variants can impair functional drainage pathways. N As well as imaging findings in acute and chronic rhinosinusitis, there are five patterns of inflammatory disease. This classification helps the surgeon to elucidate whether surgery has a role and the type of surgery to perform. N Beware of mimics of inflammatory disease such as tumours, odontogenic disease and cephalocoeles. N A wide variety of neoplasms, both benign and malignant, may arise in the sinonasal cavity. Use the pattern of bony modelling to help distinguish aggressive and non aggressive masses. N MRI is complementary to CT. T 2 weighted imaging is used for differentiating tumour and inflammatory mucosal secretions. Orbital, infratemporal, intracranial and perineural spread of disease is important. Abstract. The purpose of imaging the paranasal sinuses is to confirm diagnosis, localize the disease, characterize the extent of pathology and describe any anatomical variations. In this review article, we aim to demonstrate the complex anatomy, its variations and the appropriate imaging techniques. We will describe and illustrate the wide spectrum of disorders affecting the paranasal region and provide useful imaging features which are important for surgical planning and aid the differential diagnosis of sinonasal abnormality.
    Imaging 03/2007; 19(1):39-54. DOI:10.1259/imaging/
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    ABSTRACT: We describe the case of a 70-year-old male patient with ethmoid sinus adenocarcinoma who developed an exudative retinal detachment (ERD) in the right eye as the first manifestation. Two weeks after presentation, total regression of the ERD was noted. Extensive investigations for local causes of ERD were unrewarding. Finally, we performed a computed tomography scanning of the head that revealed an ethmoidal mass extending to the orbit. The diagnosis of adenocarcinoma was confirmed by biopsy. Neoplastic phenomena should be considered in patients presenting with temporary ERD.
    05/2013; 4(2):39-43. DOI:10.1159/000353352