The etiology of different forms of urticaria in childhood
ABSTRACT Urticaria is a common disease in children. In contrast to the ease of its diagnosis, etiologic factors are often difficult to determine. In order to study whether differences exist among various forms of urticaria in childhood and whether the patterns of different types of urticaria differ between adults and children, we extensively studied the possible causes of urticaria in children. Fifty-four children (23 girls and 31 boys; ages 1-19 years) with various forms of urticaria were included in the study. In all cases, questions about food allergies, food additive intolerance, drug intake, signs of infection, causes of physical urticaria, insect bites, and personal and family history of atopy were asked. Clinical characteristics of the disease, such as duration, recurrence, and associated angioedema and symptoms of anaphylaxis were also investigated. Detailed laboratory tests, including serologic, autoimmune, and allergic analyses, were conducted to reveal the probable etiologies of urticaria. Of the study patients, 68.5% and 31.5% were diagnosed as having acute and chronic urticaria, respectively. The patient group with chronic urticaria was older and included more boys than the acute group. In the acute urticaria group, infection was the most frequently documented cause (48.6%), followed by drugs (5.4%), and food allergies (2.7%), whereas in chronic urticaria, physical factors were the leading cause (52.94%). The most frequently documented infection was urinary tract infection, followed by serologically determined infections of Chlamydia pneumoniae and Helicobacter pylori. In this study we found indications that infections were frequently associated with urticaria, which suggests that urticaria management should include a survey of certain infectious agents in addition to a detailed history.
SourceAvailable from: Jameela Kari[Show abstract] [Hide abstract]
ABSTRACT: Key Clinical MessageWe report a case of a 9-year-old female with known end-stage kidney disease who presented with sudden onset tongue swelling. A diagnosis of angiotensin-converting enzyme inhibitor-induced angioedema related to bradykinin accumulation was made. Her symptoms resolved shortly after discontinuation of captopril. Early diagnosis can save patients from severe upper airway obstruction.04/2015; DOI:10.1002/ccr3.265
01/2015; 3(1). DOI:10.5812/jpr.152
Article: Pediatric Urticaria[Show abstract] [Hide abstract]
ABSTRACT: Urticaria in childhood is a heterogeneous disease with multiple subgroups. It is a common disease, and like in all itchy skin diseases, it has a great impact on quality of life. Epidemiological studies and available literature for pediatric urticaria is scarce, and valid data is still missing in many aspects. There seem to be no differences in the underlying causes of spontaneous urticaria between children and adults. The main focus in treating children as well as adults with urticaria is to get the patient free of symptoms and to treat the disease until it is gone. Further research is needed to provide more causal therapy options and increase quality of life in children with urticaria.06/2015; 4(2). DOI:10.1007/s13671-015-0104-7