"Both viable and nonviable probiotic microorganisms have shown to be effective in reducing the incidence and duration of diarrhoea, alleviating the clinical symptoms of lactose maldigestion and preventing candidiasis (Ouwehand & Salminen, 1998; Sanders, 2008). However, along with these beneficial effects, several side effects such as bacteremia, endocarditis and liver abscess have been reported in patients consuming probiotic products containing live bacteria (Rautio et al., 1999; Kunz et al., 2004; Mackay et al., 2008). Rachmilewitz et al. (2004) concluded that specifically DNA from bacteria may provide therapeutic effects in inflammatory disease rather than viable cells. "
[Show abstract][Hide abstract] ABSTRACT: Effects of different levels of fat and inulin on bacterial cell counts, degree of proteolysis and concentrations of organic acids in the yogurt containing inactivated cells of probiotic strains Bifidobacterium animalis and Lactobacillus acidophilus were investigated. Results showed that both L. acidophilus and B. animalis grew well in the yogurt samples reaching cell counts higher than 106 CFU mL−1 at the final pH of 4.5. Inulin at the concentration of 1% had no significant effects on the production of organic acids and cell counts of L. acidophilus, but promoted the growth of B. animalis with a reduction in the degree of proteolysis. Generally, different fat levels showed significant effects on the production of organic acids and nonsignificant effects on the cell counts of probiotic bacteria and degree of proteolysis. In case of lactic acid, the ratio of L- (+)to D- (−) isomer ranged from 50/50 to 80/20 in yogurt samples.
International Journal of Food Science & Technology 01/2014; 49(1):261-268. DOI:10.1111/ijfs.12315 · 1.38 Impact Factor
"Hp: Helicobacter pylori, AB: AB yogurt, IL-10: interleukin-10, TNF-í µí»¼: tumor necrosis factor-alpha. are immune compromised and have been reported in the literature         , so we also monitored this possible side effect. "
[Show abstract][Hide abstract] ABSTRACT: Background. The suppression of Helicobacter pylori (H. pylori) decreases H. pylori-related diseases. The probiotics have an inhibitory effect on H. pylori. Aim. We investigated the effects of long-term use of yogurt on H. pylori based on Mongolian gerbils' model. Materials and Methods. Yogurt (containing a supplement of Lactobacillus acidophilus, Bifidobacterium lactis, etc.) was used. Forty-six gerbils were divided into five groups. All groups were inoculated with H. pylori for 5 to 8 weeks. The yogurt was given as follows: Group (Gr.) A: from 1st to 4th week; Gr. B from 5th to 8th week; Gr. C: from 17th week to sacrifice; Gr. D: from 5th week to sacrifice. Gerbils were sacrificed on the 52nd week. Histology was evaluated according to the Sydney system. Results. The positive rates of H. pylori were 60% (Gr. A), 75% (Gr. B), 67% (Gr. C), 44% (Gr. D), and 100% (Gr. E). Gr. D showed lower inflammatory score. Only Gr. E (60%) had intestinal metaplasia. Gr. D showed higher IL-10 and lower TNF- α expression than Gr. E. Conclusion. Long-term intake of yogurt could decrease H. pylori infection. The long-term use of yogurt would be an alternative strategy to manage H. pylori infection.
Biochemistry Research International 11/2013; 2013:594561. DOI:10.1155/2013/594561
"Probiotics might also cause sepsis in immunocompromised populations. Septicaemia in two children with short bowel syndrome was reported who have received LGG supplementation. Premature infants, children with abnormal immune function, immunocompromised hosts, and autoimmune disorders should avoid using these products. "
[Show abstract][Hide abstract] ABSTRACT: Allergic rhinitis is a skewed immune reaction to common antigens in the nasal mucosa; current therapy is not satisfactory and can cause a variety of complications. In recent decades, the incidence of allergic rhinitis is increasing every year. Published studies indicate that probiotics are beneficial in treating allergic rhinitis. This review aims to help in understanding the role of probiotics in the treatment of allergic rhinitis. We referred to the PubMed database as data source. This review focuses on the following aspects: The types of probiotics using in the treatment of allergic rhinitis, approaches of administration, its safety, mechanisms of action, treating results, and the perspectives to improve effectiveness of probiotics in the treatment of allergic rhinitis. This review reports the recent findings regarding the role of probiotics in the treatment of allergic rhinitis. Probiotics are a useful therapeutic remedy in the treatment of allergic rhinitis, but its underlying mechanisms remain to be further investigated.
North American Journal of Medical Sciences 08/2013; 5(8):465-468. DOI:10.4103/1947-2714.117299
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