Article

DNA strand breaks induced by low keV energy heavy ions.

Laboratoire des Collisions Atomiques et Moléculaires, (Unité Mixte de Recherche CNRS-Université No 8625), Université Paris-Sud, Orsay 91405, France.
Physics in Medicine and Biology (impact factor: 2.83). 04/2004; 49(6):N65-73. pp.N65-73
Source: PubMed

ABSTRACT We present some results on the interaction of low energy atomic ions with DNA. Experiments consist of irradiation of dried DNA in vacuum with Ar ions at low keV energies for different time intervals. The DNA is placed back in solution and analysed by agarose gel electrophoresis. These experiments demonstrated the production of single and double strand breaks. The induction of these lesions could be due to several processes: direct collisions with DNA constituent atoms resulting in displacements, cascade recoil collisions of the constituent atoms, electron transfer processes between the ion and the DNA as well as breaks induced by molecular excitation and secondary electron interactions. Here we briefly discuss some aspects of direct and recoil collision processes.

0 0
 · 
0 Bookmarks
 · 
29 Views
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

analysed
 
Ar ions
 
cascade recoil collisions
 
constituent atoms
 
different time intervals
 
direct
 
direct collisions
 
displacements
 
DNA constituent atoms
 
electron transfer processes
 
induction
 
ion
 
irradiation
 
lesions
 
low energy atomic ions
 
low keV energies
 
molecular excitation
 
processes
 
recoil collision processes
 
secondary electron interactions
 

S Lacombe