Ni Mhurchu C, Rodgers A, Pan WH, Gu DF, Woodward M. Body mass index and cardiovascular disease in the Asia-Pacific Region: an overview of 33 cohorts involving 310 000 participants. Int J Epidemiol 33, 751-758
ABSTRACT Few prospective data from the Asia-Pacific region are available relating body mass index (BMI) to the risks of stroke and ischaemic heart disease (IHD). Our objective was to assess the age-, sex-, and region-specific associations of BMI with cardiovascular disease using individual participant data from prospective studies in the Asia-Pacific region.
Studies were identified from literature searches, proceedings of meetings, and personal communication. All studies had at least 5000 person-years of follow-up. Hazard ratios were calculated from Cox models, stratified by sex and cohort, and adjusted for age at risk and smoking. The first 3 years of follow-up were excluded in order to reduce confounding due to disease at baseline.
A total of 33 cohort studies, including 310 283 participants, contributed 2 148 354 person-years of follow-up, during which 3332 stroke and 2073 IHD events were observed. There were continuous positive associations between baseline BMI and the risks of ischaemic stroke, haemorrhagic stroke, and IHD, with each 2 kg/m(2) lower BMI associated a 12% (95% CI: 9, 15%) lower risk of ischaemic stroke, 8% (95% CI: 4, 12%) lower risk in haemorrhagic stroke, and 11% (95% CI: 9, 13%) lower risk of IHD. The strengths of all associations were strongly age dependent, and there was no significant difference between Asian and Australasian cohorts.
This overview provides the most reliable estimates to date of the associations between BMI and cardiovascular disease in the Asia-Pacific region, and the first direct comparisons within the region. Continuous relationships of approximately equal strength are evident in both Asian and Australasian populations. These results indicate considerable potential for cardiovascular disease reduction with population-wide lowering of BMI.
- SourceAvailable from: Jun-Hyeong Do
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- "The causes of this phenomenon are excessive ingestion of food, lack of physical activity, and environmental and genetic factors  . Obesity and abdominal obesity are potential risk factors for insulin resistance and type 2 diabetes, cardiovascular diseases, stroke, ischemic heart disease, and metabolic syndrome    , and many studies have investigated the relationship between obesity, disease, and body mass index (BMI)       . In the medical field and public health, BMI is commonly used as an indicator of overall adiposity. "
ABSTRACT: Obesity and overweight have become serious public health problems worldwide. Obesity and abdominal obesity are associated with type 2 diabetes, cardiovascular diseases, and metabolic syndrome. In this paper, we first suggest a method of predicting normal and overweight females according to body mass index (BMI) based on facial features. A total of 688 subjects participated in this study. We obtained the area under the ROC curve (AUC) value of 0.861 and kappa value of 0.521 in Female: 21-40 (females aged 21-40 years) group, and AUC value of 0.76 and kappa value of 0.401 in Female: 41-60 (females aged 41-60 years) group. In two groups, we found many features showing statistical differences between normal and overweight subjects by using an independent two-sample t-test. We demonstrated that it is possible to predict BMI status using facial characteristics. Our results provide useful information for studies of obesity and facial characteristics, and may provide useful clues in the development of applications for alternative diagnosis of obesity in remote healthcare.BioMed Research International 08/2012; 2012:834578. DOI:10.1155/2012/834578 · 2.71 Impact Factor
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- "Although worldwide consensus as to the best operations for minimizing comorbidities differs, many operations have been shown to contribute to significant reduction of obesityrelated diseases. Significant co-morbidities include type II diabetes, hypertension and stroke , hyperlipidemia , heart failure , atrial fibrillation/flutter   venous thrombosis , and obstructive sleep apnoea       . In many cases, weight loss of approximately 5–10% can be associated with marked reductions in the risk of these chronic diseases . "
ABSTRACT: Bariatric surgery is fast becoming an efficient and safe method of weight reduction, especially for patients in whom conservative measures have failed. As the obese population of the world increases, so will the number of patients requesting or requiring surgical weight loss methods. Bariatric patients however have numerous co-morbidities that make their operative course more difficult, and therefore is important to have a good understanding of the important issues surrounding their pre, peri and post operative management. This article aims to educate the reader about optimal management of the bariatric surgical patient.Journal of obesity 07/2012; 2012:781546. DOI:10.1155/2012/781546
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- "The characteristics of our study population were similar to those of the community-based Framingham Heart Study where average BMI levels, along with rates of overweight and obesity, increased with advancing age (Vasan et al., 2005). In our cohort of healthy men, higher levels of initial BMI were associated with an increased risk of CVD, results consistent with the PHS enrollment cohort (Adjani et al., 2004), a cohort of individuals without traditional CVD risk factors (Yan et al., 2006), middle-aged British men (Wannamethee et al., 2005) and prior meta-analyses evaluating baseline BMI and risk of CVD (McGee, 2004, Asia Pacific Cohort Studies Collaboration, 2004). "
ABSTRACT: To determine how change in BMI over 8 years is associated with risk of subsequent cardiovascular disease (CVD) among middle aged men. Prospective cohort study among 13,230 healthy men (aged 51.6+/-8.7 years) in the Physicians' Health Study. BMI was collected at baseline in 1982 and after 8 years, at which time follow-up began. Subsequent CVD events were collected and confirmed through March 31, 2005. Cox proportional hazards models evaluated BMI at 8 years and risk of CVD, 8-year change in BMI and risk of CVD, and whether change in BMI added prognostic information after the consideration of BMI at 8 years. 1308 major CVD events occurred over 13.5 years. A higher BMI at year 8 was associated with an increased risk of CVD. Compared to a stable BMI (+/-0.5 kg/m(2)), a 0.5-2.0 kg/m(2) increase had a multivariable-adjusted RR of 1.00 (0.86-1.16). A >/=2.0 kg/m(2) increase had a multivariable-adjusted RR of 1.39 (1.16-1.68), however further adjustment for BMI reduced the RR to 1.00 (0.81-1.23). A decrease in BMI had a multivariable RR of 1.23 (1.07-1.42) which was unaffected by adjustment for BMI at 8 years. A higher BMI and a rising BMI were both associated with an increased risk of CVD, however an increasing BMI did not add prognostic information once current BMI was considered. In contrast, a declining BMI was associated with an increased risk of CVD independent of current BMI.Preventive Medicine 12/2007; 45(6):436-41. DOI:10.1016/j.ypmed.2007.06.022 · 2.93 Impact Factor