Effects of antibody on viral kinetics in simian/human immunodeficiency virus infection: implications for vaccination.

Department of Haematology, Prince of Wales Hospital and Centre for Vascular Research, University of New South Wales, Kensington, New South Wales 2052, Australia.
Journal of Virology (Impact Factor: 4.65). 06/2004; 78(10):5520-2. DOI: 10.1128/JVI.78.10.5520-5522.2004
Source: PubMed

ABSTRACT Passive antibody treatment of macaques prior to simian/human immunodeficiency virus infection produces "sterilizing immunity" in some animals and long-term reductions in viral loads in others. Analysis of viral kinetics suggests that antibody mediates sterilizing immunity by its effects on the initial viral inoculum. By contrast, reduction in peak viral load later in infection prevents CD4 depletion and contributes to long-term viral control.

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