Bipolar-panic disorder comorbidity within bipolar disorder families: a study of siblings.
ABSTRACT Although anxiety disorders often co-occur with bipolar disorder in clinical settings, relatively few studies of bipolar disorder have looked specifically at panic comorbidity. This report examines lifetime panic comorbidity within a sample of families with a history of bipolar disorder.
One hundred and nine probands with bipolar disorder and their 226 siblings were interviewed as part of a family-genetic study. Logistic regression was used to model bipolar disorder as a predictor of comorbid panic in those with affective disorder, with age at interview and gender included as covariates.
The percentage with panic attacks was low in those without affective disorder (3%) compared with those with unipolar depression (22%) or bipolar disorder (32%). Panic disorder was found only in those with affective disorder (6% for unipolar, 16% for bipolar). When bipolar disorder and unipolar disorder were compared, controlling for age and sex, having bipolar disorder was associated with panic disorder (OR = 3.0, 95% CI = 1.1, 7.8) and any panic symptoms (OR = 2.0, CI = 1.0,3.8) and more weakly with the combination of panic disorder and recurrent attacks (OR = 1.8, CI = 0.9, 3.5).
The absence of panic disorder and the low prevalence of any panic symptoms in those without bipolar or unipolar disorder suggest that panic is associated primarily with affective disorder within families with a history of bipolar disorder. Furthermore, panic disorder and symptoms are more common in bipolar disorder than in unipolar disorder in these families.
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ABSTRACT: Introduction: Bipolar disorder is a serious mental illness, but medications and psychosocial approaches designed to treat it leave significant room for improvement. This study investigated Progressive Muscle Relaxation (PMR), a treatment originally designed to reduce anxiety, as a way to reduce manic symptoms. Methods: Participants with bipolar I disorder (n = 44) were assigned via stratified randomization to complete PMR or a control condition (self-focused calming). Participants underwent a positive mood induction procedure, and completed several measures of manic symptoms at Session 1 and Session 2 (several weeks later). Results: Among those who experienced a successful positive mood induction, PMR and the control condition generally resulted in similar reductions in high-arousal positive affect. Participants who practiced PMR between the two sessions tended to experience greater reductions in positive affect at Session 2 compared to those who did not practice. Discussion: The relative parity of the PMR and control conditions suggests that people with bipolar I disorder have effective strategies for regulating positive emotions. Rather than teaching additional strategies, it may be more fruitful to develop methods for helping people with bipolar disorder to implement the strategies that work for them.
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ABSTRACT: Riassunto. Il disturbo bipolare si riscontra spesso in comorbidità con il disturbo di panico. Rispetto a pazienti bipolari senza disturbo di panico questi soggetti hanno aumentati livelli di psicopatologia, età di insorgenza precoce sia del disturbo bipolare che del disturbo di panico, sintomi di panico particolarmente intensi ed elevata comorbidità per patologie polmonari. Dall'analisi della letteratura si evidenzia che tale condizione sembra essere in realtà un sottotipo distinto di disturbo bipolare, contraddistinto da caratteristiche cliniche peculiari, espressione di un assetto genetico specifico, sebbene non siano ancora chiari i geni coinvolti nella patogenesi. Lo studio di questo fenotipo potrà portare, oltre ad una maggiore accuratezza diagnostica, allo sviluppo di opportuni algoritmi terapeutici. Summary. Bipolar disorder frequently co-occurs with panic disorder. These patients report higher psychopathology, earlier onset of illness both for bipolar and for panic disorder, greater panic symptomatology and significant increases in lung disease, compared with those with bipolar disorder without panic attack. Reviewing the literature, bipolar-panic comorbidity may reflect a syndromal subtype of affective illness, with peculiar clinical pictures, deriving from a specific genetic loading, although genes involved are not still delighted. Future studies that examine this phenotype should bring, other than a better diagnostic accuracy, to the development of specific guidelines.
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ABSTRACT: A radar imaging method for terrain is introduced in which the radar is suspended in the air, but the radar antenna is rotating. The relation between echo signals and the terrain image (the absolute value of terrain reflectivity) is examined. An imaging method called equal-range projection deconvolution is the derived, and an algorithm reconstructing the terrain image is givenAcoustics, Speech, and Signal Processing, 1988. ICASSP-88., 1988 International Conference on 01/1988; DOI:10.1109/ICASSP.1988.196814 · 4.63 Impact Factor