Article

Plasminogen activator inhibitor type-1: Its structure, biological activity and role in tumorigenesis (Review)

Department of Laboratory Diagnostics and Immunology, National Institute of Tuberculosis and Lung Diseases, Warsaw, Poland.
International Journal of Molecular Medicine (Impact Factor: 1.88). 07/2004; 13(6):759-66. DOI: 10.3892/ijmm.13.6.759
Source: PubMed

ABSTRACT Plasminogen activator inhibitor type-1 (PAI-1), is a unique member of serpin superfamily, the primary regulator of plasminogen activation and therefore essential factor regulating physiological thrombotic/fibrinolytic balance in vivo. Via interactions with integrins and extracellular matrix components it orchestrates also cell adhesion and migration. Therefore, PAI-1 is considered one of the key regulators of tumor invasion and metastasis, as well as cancer-related angiogenesis. This review summarizes recent findings on the structure and functional activity of the plasminogen activator inhibitor type-1, and current opinions on its role in tumorigenesis.

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    • "are the spesific point mutations that have been reported as a risk factors for the development of venous thrombosis for Factor V gene (Zaatari et al., 2006). The plasminogen activator inhibitor-1 gene (PAI-1) is an essential regulator of plasminogen activation and has been linked to the pathogenesis of lung carcinomas (Pavey et al., 1996; Chorostowska-Wynimko et al., 2004). The angiotensinconverting enzyme (ACE) is a zinc metallopeptidase that plays an important role in the blood pressure and inflammation. "
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    • "The fibrinolytic system also plays an important role in tumorigenesis. Plasminogen activator inhibitor-1 (PAI-1) is one of the key regulators of tumor invasion, metastasis and cancer related angiogenesis (Falanga and Rickles, 1999; Chorostowska-Wynimko et al., 2004). Whole blood thromboelastography (TEG Haemoscope) evaluates primary hemostasis, secondary hemostasis, the fibrinolytic system, and clot strength. "
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