Division of Infectious Diseases, Children's Hospital of Eastern Ontario, 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada.
Canadian Medical Association Journal (Impact Factor: 5.96). 06/2004; 170(11):1693-702.
Source: PubMed Central


Malaria is a parasitic infection of global importance. Although relatively uncommon in developed countries, where the disease occurs mainly in travellers who have returned from endemic regions, it remains one of the most prevalent infections of humans worldwide. In endemic regions, malaria is a significant cause of morbidity and mortality and creates enormous social and economic burdens. Current efforts to control malaria focus on reducing attributable morbidity and mortality. Targeted chemoprophylaxis and use of insecticide-treated bed nets have been successful in some endemic areas. For travellers to malaria-endemic regions, personal protective measures and appropriate chemoprophylaxis can significantly reduce the risk of infection. Prompt evaluation of the febrile traveller, a high degree of suspicion of malaria, rapid and accurate diagnosis, and appropriate antimalarial therapy are essential in order to optimize clinical outcomes of infected patients. Additional approaches to malaria control, including genetic manipulation of mosquitoes and malaria vaccines, are areas of ongoing research.

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    • "Malaria is one of the most widespread diseases in the world. It is endemic throughout the tropical and subtropical regions of the world [1,2]. Malaria remains a public health problem in Malaysia, especially in the state of Sabah, Sarawak and in the interior central regions of Peninsular Malaysia where Perak, Pahang and Kelantan share their borders and where the population is made up of aborigines [3]. "
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    Malaria Journal 12/2011; 10(1):361. DOI:10.1186/1475-2875-10-361 · 3.11 Impact Factor
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    • "Malaria remains a major cause of morbidity and mortality in sub-Saharan Africa [1]. Worldwide malaria morbidity is estimated to be 300–500 million cases and about 1 million deaths each year, of which 90% occur in sub-Saharan Africa [2,3]. The vast majority of deaths occur among children below five years of age and pregnant women, especially in remote rural areas with poor access to health services [4]. "
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    ABSTRACT: Site preparation is a pre-requesite in conducting malaria vaccines trials. This study was conducted in 12 villages to determine malariometric indices and associated risk factors, during long and short rainy seasons, in an area with varying malaria transmission intensities in Korogwe district, Tanzania. Four villages had passive case detection (PCD) of fever system using village health workers. Four malariometric cross-sectional surveys were conducted between November 2005 and May 2007 among individuals aged 0-19 years, living in lowland urban, lowland rural and highland strata. A total of 10,766 blood samples were collected for malaria parasite diagnosis and anaemia estimation. Blood smears were stained with Giemsa while haemoglobin level was measured by HaemoCue. Socio-economic data were collected between Jan-Apr 2006. Adjusting for the effect of age, the risk of Plasmodium falciparum parasitaemia was significantly lower in both lowland urban, (OR = 0.26; 95%CI: 0.23-0.29, p < 0.001) and highlands, (OR = 0.21; 95%CI: 0.17-0.25, p < 0.001) compared to lowland rural. Individuals aged 6-9 years in the lowland rural and 4-19 years in both lowland urban and highlands had the highest parasite prevalence, whilst children below five years in all strata had the highest parasite density. Prevalence of splenomegaly and gametocyte were also lower in both lowland urban and highlands than in lowland rural. Anaemia (Hb <11 g/dl) prevalence was lowest in the lowland urban. Availability of PCD and higher socio-economic status (SES) were associated with reduced malaria and anaemia prevalence. Higher SES and use of bed nets in the lowland urban could be the important factors for low malaria infections in this stratum. Results obtained here were used together with those from PCD and DSS in selecting a village for Phase 1b MSP3 vaccine trial, which was conducted in the study area in year 2008.
    Malaria Journal 02/2009; 8(1):165. DOI:10.1186/1475-2875-8-165 · 3.11 Impact Factor
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    Canadian Medical Association Journal 11/2004; 171(9):1023; author reply 1023-4. DOI:10.1503/cmaj.1041374 · 5.96 Impact Factor
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