Article

Association between cerebral ischemia and cytotoxin-associated gene-A-bearing strains of Helicobacter pylori.

Department of Neurology, University of Heidelberg, Germany.
Stroke (impact factor: 5.73). 08/2004; 35(8):1800-4. DOI:10.1161/01.STR.0000131751.35926.48 pp.1800-4
Source: PubMed

ABSTRACT Studies on Helicobacter pylori infection and risk of ischemic stroke yielded variable results. Infection with more virulent H. pylori strains, such as cytotoxin-associated gene-A (CagA)-bearing strains, may be of particular relevance for ischemic diseases. We investigated whether H. pylori and CagA seropositivity are independent risk factors for cerebral ischemia or its etiologic subtypes.
We determined IgG antibodies against H. pylori and CagA protein (enzyme immunoassays) in 190 patients with acute cerebral ischemia and in 229 age- and sex-matched control subjects selected randomly from the general population.
CagA seropositivity was more common in patients (114/190; 60.0%) than in control subjects (99/229; 43.2%; odds ratio, 1.97; 95% CI, 1.33 to 2.91; P<0.001). This result remained significant after adjustment for age, sex, vascular risk factors and diseases, and childhood and adult social status (odds ratio, 1.84; 95% CI, 1.13 to 3.00; P=0.015). Subgroup analyses yielded similar results in all etiologic stroke subtypes. In contrast, H. pylori seropositivity in general was not associated with increased risk of stroke or its etiologic subtypes.
Our results support the hypothesis of an association between infection with CagA-positive H. pylori strains and acute cerebral ischemia.

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    Article: Helicobacter pylori serum antibody titers in patients with cerebral non-cardioembolic ischemic stroke.
    Seyed Ali Mousavi, Behrooz Ataei, Iraj Karimi, Kamyar Ashrafi
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    ABSTRACT: Helicobacter pylori (H. pylori) infection has been associated with atherosclerosis of coronary arteries but there is lack of data regarding possible association between chronic H. Pylori infection and cerebral non-cardioembolic ischemia. We evaluated H. pylori serum antibody titers in patients with cerebral non-cardioembolic ischemic stroke. This was a cross-sectional study carried out in Alzahra hospital, Isfahan, Iran. 96 patients with ischemic stroke were enrolled in this study. Control group were selected from healthy blood donors. IgG and IgA antibodies to H. pylori were detected using a rapid enzyme linked immunosorbent assay. Quantitative variables and categorical variables were compared using t student and chi-square tests. There were 21 cases of hypertension and 5 cases of diabetes mellitus among patients. Patients and controls were similar regarding serum IgA and IgG titers as well as positivity. There were 13 and 15 cases of positive IgA and 44 and 39 cases of positive IgG among patients and controls, respectively. Also, there were 7 and 9 cases of both positive IgA and IgG in patients and controls, respectively. No differences were found between the two groups in IgA or IgG titers or positivity (p > 0.05). Patients with stroke were not different regarding either H. Pylori IgA or IgG positivity or the antibody titers. Comparing genetic typing of H. pylori in patients with or without stroke and diagnosis of H. pylori with more specific and sensitive tests such as stool antigen test are recommended.
    Journal of research in medical sciences 03/2011; 16 Suppl 1:S407-11. · 0.46 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

acute cerebral ischemia
 
adult social status
 
CagA protein
 
CagA-positive H. pylori strains
 
cerebral ischemia
 
control subjects
 
cytotoxin-associated gene-A
 
etiologic stroke subtypes
 
general population
 
H. pylori
 
H. pylori seropositivity
 
Helicobacter pylori infection
 
ischemic diseases
 
ischemic stroke
 
results support
 
sex-matched control subjects
 
similar results
 
variable results
 
vascular risk factors
 
virulent H. pylori strains
 

Michael R Preusch