[Reference values of MRI flow measurements of the pulmonary outflow tract in healthy children].
ABSTRACT To provide reference values for MRI-based flow measurements in the main pulmonary artery in healthy children.
In 98 healthy children (age: 3 - 17 years, median: 11 years), the main pulmonary artery was examined using MRI-based flow measurements with high temporal resolution (9.6 ms per cardiac phase).
The acceleration time revealed a distinct age dependency and varied between 90 and 155 ms (mean: 124 ms +/- 14). The relative acceleration time (related to the RR-interval) varied between 12.7 and 27 % (mean: 18 % +/- 2.6). The mean values and the standard deviations for the determined values were as follows: cardiac output (5.4 l/min +/- 1.4), cardiac output normalized to the body surface area (4.2 [l/min]/m(2) +/- 0.8), average systolic flow velocity (66 cm/s +/- 12), maximum systolic flow (309 ml/s +/- 79), mean flow (110 ml/s +/- 30), distensibility of the wall of the main pulmonary artery (79 % +/- 26), peak velocity (96 cm/s +/- 15), pressure gradient along the pulmonary valve (3.8 mm Hg +/- 1.2), stroke volume (63.2 ml +/- 17.9), acceleration volume (23.7 ml +/- 8.7), maximum acceleration of flow (4924 ml/s(2) +/- 1431), and reverse volume (0.2 ml +/- 0.3).
The acquired values of reference are applicable to all pediatric patients and serve as a framework for the communication between the radiologist and the pediatric cardiologists. High temporal resolution of the measurement sequence is mandatory. Noticeable deviations of these values should induce additional (probably invasive) evaluation.
Article: Evaluation of a resistance-based model for the quantification of pulmonary arterial hypertension using MR flow measurements.[show abstract] [hide abstract]
ABSTRACT: To establish an estimate for the mean pulmonary arterial pressure (mPAP) derived from noninvasive data acquired with magnetic resonance (MR) velocity-encoded sequences. In seven sedated pigs synchronous catheter-based invasive pressure measurements (IPM) and noninvasive MR were acquired in the main pulmonary artery (MPA) at different severities of pulmonary arterial hypertension (PAH) that were caused by infusion of thromboxane A2 (TxA2). The invasively measured mPAP was correlated with the noninvasive MR velocity data and linear combination equations (LCE) were computed. Intravenously applied TxA2 induced a dose dependent level of severity of PAH with an mPAP of up to 54 mmHg without systemic effects. The acceleration time (AT) measured with MR demonstrated the best correlation with the mPAP (r(2) = 0.75). The LCE with the highest correlation (R = 0.945, alpha < 0.01) between IPM and MR revealed a mean difference of 0, a SD of s = 4.66 and a maximal difference of 12.2 mmHg using the Bland-Altman analysis. Applying the identified LCE allowed the estimation of the mPAP in an acute and resistance-based model of PAH with high accuracy using noninvasive MR velocity-encoded sequences.Journal of Magnetic Resonance Imaging 09/2007; 26(3):646-53. · 2.70 Impact Factor