Article

[Idiopathic polypoidal choroidal vasculopathy].

Servicio de Oftalmología, Hospital Miguel Servet, Zaragoza.
Archivos de la Sociedad Espanola de Oftalmologia 06/2004; 79(5):229-35. pp.229-35
Source: PubMed

ABSTRACT To evaluate the incidence, clinical features and evolution of polypoidal choroidal vasculopathy (PCV) in our population.
Retrospective study of patients diagnosed with exudative and/or hemorrhagic maculopathy including age-related macular degeneration in the last two years and who have undergone a complete ophthalmologic exploration and videoangiography with fluorescein and indocyanine green.
250 patients were included in the study, 8 patients (3.2%) had clinical and angiographic criteria of PCV. The mean age was 68 years-old, 62.5% were men and 85.7% were caucasian. Ninety percent of cases presented clinically as a predominantly hemorrhagic macular detachment. The initial clinical diagnosis before indocyanine green angiography was exudative age-related macular degeneration in 90% of cases. The mean visual acuity was 0.2 at baseline and after follow-up. Laser treatment was performed in 4 eyes, achieving good anatomic and visual acuity results in 2 of them; both eyes of one patient were treated by photodynamic therapy with poor angiographic and functional outcome.
Polypoidal choroidal vasculopathy is a clinical entity which is relatively frequent among patients previously diagnosed with exudative maculopathy. Indocyanine green angiography increases the number of correct diagnoses. Treatment must be individualized depending on the location of the lesions and the severity of the disease.

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    Article: Analysis of candidate genes for age-related macular degeneration subtypes in the Japanese population.
    Koji Tanaka, Tomohiro Nakayama, Mitsuko Yuzawa, Zhaoxia Wang, Akiyuki Kawamura, Ryusaburou Mori, Hiroyuki Nakashizuka, Naoyuki Sato, Yoshihiro Mizutani
    [show abstract] [hide abstract]
    ABSTRACT: Age-related macular degeneration (AMD) is thought to be a polygenetic disease. It is divided into three subtypes; neovascular AMD (nAMD), polypoidal choroidal vasculopathy, and retinal angiomatous proliferation (RAP). These subtypes are thought to have different pathophysiological and genetic backgrounds. We aimed to investigate the relationships between single nucleotide polymorphisms (SNPs) in candidate genes and subtypes of AMD in the Japanese population. We genotyped 685 AMD patients and 277 controls for four SNPs of the selected candidate genes: rs800292 in complement factor H, rs10490924 in age-related maculopathy susceptibility 2 (ARMS2), rs2301995 in elastin (ELN), and rs1801133 in methylenetetrahydrofolate reductase (MTHFR). Case-control studies were performed using these AMD subtypes. Logistic regression analysis was performed using a history of hypertension, diabetes mellitus, and smoking as cardiovascular risks. The genotype-dominant or recessive distribution of all four SNPs differed significantly between the controls and the AMD patients. In the subtype analysis, there were significant differences between the controls and the AMD patients in genotype distributions. This was true for all AMD subtype analyses of both rs800292 (complement factor H) and rs10490924 (ARMS2). Logistic regression analysis indicated the TT genotype of the ARMS2 gene to be significantly more common in RAP patients (p=1.54×10(-13), odds ratio: 22.18). In contrast, there were significant differences in the genotype distribution between the controls and nAMD patients only for rs2301995 (ELN, p=0.022) and rs1801133 (MTHFR, p=2.50×10(-3)). Our results indicate that SNPs of the ARMS2 gene may serve as strong genetic markers of RAP, and that SNPs of the ELN and MTHFR genes are potential genetic markers for nAMD.
    Molecular vision 01/2011; 17:2751-8. · 2.20 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

4 eyes
 
8 patients
 
age-related macular degeneration
 
complete ophthalmologic exploration
 
correct diagnoses
 
exudative maculopathy
 
functional outcome
 
hemorrhagic macular detachment
 
hemorrhagic maculopathy
 
indocyanine green
 
indocyanine green angiography
 
initial clinical diagnosis
 
Laser treatment
 
mean age
 
mean visual acuity
 
patients
 
photodynamic therapy
 
Polypoidal choroidal vasculopathy
 
poor angiographic
 
visual acuity results