Resolution of calcific brown fat necrosis associated with prostaglandin therapy for cyanotic congenital heart disease in neonates: Report of two cases

Department of Diagnostic Imaging, The Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada M5G 1X8.
Pediatric Radiology (Impact Factor: 1.57). 12/2004; 34(11):919-23. DOI: 10.1007/s00247-004-1231-7
Source: PubMed


Prostaglandin E1 (PGE1) administration for palliation of cyanotic congenital heart disease in neonates has been associated with radiographically visible necrosis of brown fat about the neck and shoulder girdles. However, the natural history of this process has not been described. We present two patients with cyanotic congenital heart disease, treated preoperatively with prostaglandin E2 (PGE2), both of whom developed dramatic calcific brown fat necrosis. This process slowly resolved over time in both patients.

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