Article

Correlation between penile duplex findings and stress electrocardiography in men with erectile dysfunction

Cairo University, Andrology Department, Cairo, Egypt.
International Journal of Impotence Research (Impact Factor: 1.37). 07/2004; 16(3):235-7. DOI: 10.1038/sj.ijir.3901148
Source: PubMed

ABSTRACT The aim of this work is to assess the association between vasculogenic erectile dysfunction (ED) and coronary artery disease in men above the age of 40 y. The study included 40 patients above 40 y of age with vasculogenic ED of more than 3 months duration. A dynamic duplex study after intracavernosal injection of a bimix solution (60 mg papaverine + 2 mg phentolamine mesylate) was carried out using a color ultrasound machine. The patients underwent a stress ECG test, carried out on a motor-driven treadmill according to the 'Bruce Protocol'. A total of 12 patients were diagnosed with positive ischemic heart disease (IHD). Their mean peak systolic velocity (PSV) was PSV = 19.58 cm/s. In all, patients were diagnosed with negative IHD; their mean PSV was 36.21 cm/s. A statistically significant difference was observed between patients with positive IHD and patients with negative IHD regarding PSV (P = 0.003). The sensitivity of a PSV of less than 35 cm/s in predicting IHD was 50% with a specificity of 100%. Positive predictive value for abnormal stress ECG to predict a PSV of less than 35 cm/s was 100%. In conclusion, the PSV of cavernosal arteries is a reliable measure for predicting IHD in patients with vasculogenic ED. Patients with a PSV of less than 35 cm/s should be referred for cardiologic assessment as they carry a real risk of having silent IHD.

0 Bookmarks
 · 
73 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Transdermal drug delivery has given cardinal contribution to medical practices. First-generation transdermal delivery of small, lipophilic, low-dose drugs and second-generation delivery systems using chemical enhancers, non-cavitational ultrasound and iontophoresis have also resulted in various clinical products provides added functionality. Third-generation delivery systems using microneedles, thermal ablation, microdermabrasion, electroporation and cavitational ultrasound targeting skin's barrier layer of stratum corneum. Microneedles acquire pronounced intrigue in recent days. Currently, microneedles are advancing through clinical trials for delivery of macromolecules and vaccines, such as insulin, parathyroid hormone and influenza vaccine. The review explains about the concept of transdermal drug microneedle system comprising of microreservoir, micropumps, flow sensors, types of microneedles. Various researches carried out on these components of microneedle system is elaborately discussed in this review.
    Microsystem Technologies 07/2014; 20(7). DOI:10.1007/s00542-014-2233-5 · 0.95 Impact Factor
  • Source
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Objective To review the contemporary knowledge of local investigations in the Arab countries that were conducted to identify the magnitude of erectile dysfunction (ED) and its correlates among men in this region.MethodsMEDLINE was reviewed for English-language reports from 2000 to 2011 for Arab countries, using the terms ‘erectile dysfunction’ and ‘prevalence’.ResultsIn all, 102 articles were found to be relevant to the review. Unfortunately only a few had a high level of evidence and the remaining studies were not controlled in their design. Several local studies showed that the prevalence of ED was >40% among Arab men. Risk factors and medical comorbidities that negatively affect the cardiovascular system, endothelial function and ultimately erectile function were common in men in Arab countries. For instance, at least five Arab countries are included in the top 10 countries worldwide with a high prevalence of diabetes mellitus. The global statistics showed that other risk factors such as obesity, smoking, hypertension and dyslipidaemia are also very prevalent in Arab countries. This fact can explain the high incidence of both cardiovascular disease and ED among Arab men.ConclusionED is very prevalent among Arab men. Arab countries are among those with the highest prevalence of endothelial dysfunction risk factors, which could explain this high prevalence of ED.
    06/2012; 10(2):97–103. DOI:10.1016/j.aju.2012.01.004

Full-text (2 Sources)

Download
21 Downloads
Available from
Jun 10, 2014