Article

Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial. Effects of wine on inflammatory markers.

Department of Internal Medicine, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Atherosclerosis (Impact Factor: 3.97). 08/2004; 175(1):117-23. DOI: 10.1016/j.atherosclerosis.2004.03.006
Source: PubMed

ABSTRACT No intervention studies have explored the anti-inflammatory effects of different alcoholic beverages on markers of atherosclerosis. We embarked on a randomized, crossover, single-blinded trial to evaluate the effects of wine and gin on inflammatory biomarkers of atherosclerosis.
Forty healthy men (mean age, 37.6 years) consumed 30 g ethanol per day as either wine or gin for 28 days. Before and after each intervention, we measured the expression of lymphocyte function-associated antigen 1 (LFA-1), Mac-1, very late activation antigen 4 (VLA-4), and monocyte chemoattractant protein (MCP-1) in monocytes, as well as the soluble vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), interleukin-1alpha (IL-1alpha), C-reactive protein (hs-CRP) and fibrinogen. After either gin or wine consumption, plasma fibrinogen decreased by 5 and 9%, respectively, and cytokine IL-1alpha by 23 and 21%. The expression of LFA-1 (-27%), Mac-1 (-27%), VLA-4 (-32%) and MCP-1 (-46%) decreased significantly after wine, but not after gin. Wine reduced the serum concentrations of hs-CRP (-21%), VCAM-1 (-17%) and ICAM-1 (-9%).
Both wine and gin showed anti-inflammatory effects by reducing plasma fibrinogen and IL-1alpha levels. However, wine had the additional effect of decreasing hs-CRP, as well as monocyte and endothelial adhesion molecules.

0 Bookmarks
 · 
101 Views
  • [Show abstract] [Hide abstract]
    ABSTRACT: Evidences accumulated over the last thirty years suggest that light to moderate alcohol consumption, especially in the form of red wine, can have beneficial effects for health. Those benefits mostly refer to improvement in cardiovascular health, although relationships with a lower risk of other pathologies such as type 2 diabetes, dementia or cognitive decline in old age have also been established. Most evidences derive from observational studies or from in vitro or animal assays, whereas direct scientific data in human are scarce and incomplete. On the other hand, alcohol is a toxic product whose irresponsible and excessive consumption has well-established consequences for health and serious social implications. Furthermore, some adverse effects have been related with the moderate consumption of alcoholic beverages, including an increase in the incidence of different types of cancer. In this article, a revision about the current knowledge about alcohol and health relationships is made, paying particular attention to the case of red wine.
    Ciência e Técnica Vitivinícola 12/2010; 26(1):33-44. · 0.10 Impact Factor
  • Source
    Revista Clínica Española 02/2014; · 1.31 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Background and aims Moderate alcohol consumption exerts a cardioprotective effect, but no studies have evaluated the alcohol-independent cardiovascular effects of the non-alcoholic components of beer. We aimed to evaluate the effects of ethanol and the phenolic compounds of beer on classical and novel cardiovascular risk factors. Methods and results Thirty-three high-risk, male volunteers were included in a randomized, crossover feeding trial. After a washout period, all subjects received beer (30 g alcohol/d, 660 mL), the equivalent amount of polyphenols as non-alcoholic beer (990 mL), and gin (30 g alcohol/d, 100 mL) for 4 weeks. All outcomes were evaluated before and after each intervention period. Moderate alcohol consumption increased serum HDL-cholesterol (∼5%), ApoA-I (∼6%), ApoA-II (∼7%) and adiponectin (∼7%), and decreased serum fibrinogen (∼8%), and interleukin (IL)-5 (∼14%) concentrations, whereas the non-alcoholic fraction of beer (mainly polyphenols) increased the receptor agonist of IL-1ra (∼24%), and decreased lymphocyte expression of lymphocyte function-associated antigen-1 (∼11%), lymphocyte and monocyte expression of Sialil-Lewis X (∼16%) and monocyte expression of CCR2 (∼31%), and tumor necrosis factor (TNF)-β (∼14%) and IL-15 (∼22%) plasma concentrations. No changes were observed in glucose metabolism parameters or in body weight and adiposity parameters. Conclusion The phenolic content of beer reduces leukocyte adhesion molecules and inflammatory biomarkers, whereas alcohol mainly improves the lipid profile and reduces some plasma inflammatory biomarkers related to atherosclerosis. Trial registration number: ISRCTN95345245 (http://www.isrctn.org/).
    Nutrition Metabolism and Cardiovascular Diseases 08/2014; · 3.88 Impact Factor

Full-text (2 Sources)

Download
35 Downloads
Available from
May 23, 2014