Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: A prospective randomized crossover trial. Effects of wine on inflammatory markers

Department of Internal Medicine, Hospital Clinic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain.
Atherosclerosis (Impact Factor: 3.99). 08/2004; 175(1):117-23. DOI: 10.1016/j.atherosclerosis.2004.03.006
Source: PubMed

ABSTRACT No intervention studies have explored the anti-inflammatory effects of different alcoholic beverages on markers of atherosclerosis. We embarked on a randomized, crossover, single-blinded trial to evaluate the effects of wine and gin on inflammatory biomarkers of atherosclerosis.
Forty healthy men (mean age, 37.6 years) consumed 30 g ethanol per day as either wine or gin for 28 days. Before and after each intervention, we measured the expression of lymphocyte function-associated antigen 1 (LFA-1), Mac-1, very late activation antigen 4 (VLA-4), and monocyte chemoattractant protein (MCP-1) in monocytes, as well as the soluble vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), interleukin-1alpha (IL-1alpha), C-reactive protein (hs-CRP) and fibrinogen. After either gin or wine consumption, plasma fibrinogen decreased by 5 and 9%, respectively, and cytokine IL-1alpha by 23 and 21%. The expression of LFA-1 (-27%), Mac-1 (-27%), VLA-4 (-32%) and MCP-1 (-46%) decreased significantly after wine, but not after gin. Wine reduced the serum concentrations of hs-CRP (-21%), VCAM-1 (-17%) and ICAM-1 (-9%).
Both wine and gin showed anti-inflammatory effects by reducing plasma fibrinogen and IL-1alpha levels. However, wine had the additional effect of decreasing hs-CRP, as well as monocyte and endothelial adhesion molecules.

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    • "There is an inverse correlation between alcoholic beverage consumption and lymphocyte levels of 8- hydroxydeoxyguanosine, the primary marker for cancer (Bianchini et al., 2001). However, wine and other alcoholic beverages have also been associated with some negative effects including decreased levels of WBC which shows an independent association (Nakanishi et al., 2003; Estruch et al., 2004; Imhof et al., 2004), though some studies have reported otherwise (Shaper et al., 1985; Oduola et al., 2005) and have also reported on the highly positive and negative association of alcohol with other haematological parameters. It is necessary to see in this study, whether the aforementioned reports on the haematological parameters considered in previous studies apply to the administration of multi-fruit wine produced, to what extent it does and most importantly if variations exist in these indices among male and female sexes. "
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    ABSTRACT: This study was aimed at evaluating the impact of wine obtained from a blend of five fruit extracts on some haematogical indices of male and female albino Wistar rats. Seventy male and female rats were randomly divided on the basis of body weight and sex into seven study groups. Group I (normal control) received normal diet and distilled water only, while the other groups except VI and VII (which had low doses of standard red and cashew wines respectively) received either low (corresponding to four standard drinks) or high (six standards) doses of the respective multi-fruit wine samples. Haematological indices determined showed that Hb and RBC values were not altered in both sexes compared with the control. The WBC values of all the test groups of female and male rats decreased significantly (P<0.05) compared with the normal control except H-MFWA (high dose of multi-fruit wine with additives) in females which compared well with the normal control. General decrease in MCV values of females and increase in males were significant (P<0.05) in some cases when compared with the normal control. Results of the investigation showed that sex differences associated with the handling of alcohol toxicity in the serum exist among male and female rats with the administration of multi-fruit wine. It also suggests the possible role of phytochemicals and wine additives in influencing the outcome of certain haematological parameters.
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    • "We adjusted for health status, but inevitably we did not have a completely comprehensive assessment of health status. It is also possible that low to moderate alcohol use may result in less lung restriction and lower inflammatory responses , supported by some interventional studies (Beulens et al., 2008; Estruch et al., 2004; Joosten et al., 2008 "
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    ABSTRACT: In Western settings, moderate drinking is negatively associated with respiratory disease. However, moderate drinking is socially patterned, making this association vulnerable to contextual biases. Evidence from other contexts where the typical drinking pattern is different may clarify such observations. Multivariable Cox regression analysis was used to assess the adjusted associations of alcohol use with death from respiratory disease using a population-based prospective cohort of 66,820 Chinese aged ≥65years enrolled from July 1998 to December 2001 at all the 18 Elderly Health Centers of the Hong Kong Government Department of Health and followed till May 30, 2012. During ten-year follow-up, 4065 deaths from respiratory disease occurred. Most current drinkers were occasional drinkers (<1day/week). Both moderate and occasional drinking (<1day/week) were associated with a lower risk of death from respiratory disease, but the point estimates and pattern of associations were similar between these two types of drinkers. The typical drinking pattern, i.e. occasional drinking (<1day/week), which is unlikely to have any biological effect, was similarly associated with a lower risk of respiratory disease as moderate alcohol use, suggesting the attributes of being a typical drinker may be protective.
    Preventive Medicine 09/2013; 57(6). DOI:10.1016/j.ypmed.2013.09.011 · 3.09 Impact Factor
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    • "Moderate alcohol consumption (1-2 drinks per day) has been reported to be associated with improved insulin sensitivity [1] [2] and lower risk of cardiovascular disease (CVD) in humans [3] [4]. Red wine is supposed to exert an evident protective effect on cardiovascular system, and nonalcoholic components, such as polyphenols in the red wine, might play a significant role in its protection effects [5] [6] [7]. In addition, alcohol could decrease tissue polyunsaturated fatty acids (PUFA) including C20:4n-6 and C22:6n-3 in animal studies [8] [9] [10] [11], while this decrease could be attenuated or even reversed by red wine consumption, which might be attributed to the effects of nonalcoholic components [9] [10]. "
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    ABSTRACT: Objective. To examine the effect of two Chinese liquors with quite different nonalcoholic components on insulin sensitivity, tissue polyunsaturated fatty acids (PUFA), and hepatic lipid metabolism in SD rats. Methods. Thirty-three SD rats were randomized into four groups and maintained in each treatment for 10 weeks: Chinese tea-flavor liquor (TFL, n = 9), traditional Chinese liquor (TCL, n = 8), ethanol control (EC, n = 8), and water control (WC, n = 8). Results. TFL significantly decreased plasma insulin (p = 0.009) and marginally decreased HomeostaticModel Assessment-Insulin Resistance (HOMA-IR) (p = 0.05), compared with WC.Hepatic total and n-6 PUFA compositions were significantly decreased in TFL, TCL, and EC groups compared withWC group (p < 0.05). TFL significantly increased kidney n-6 PUFA (p = 0.05) and total PUFA (p = 0.039), compared with EC group. EC group showed significant higher gene expressions of acetyl-CoA carboxylase and steroid response element-binding protein (1c and 2), while there were no significant differences of these gene expressions in TFL or TCL group compared with WC. Conclusions. TFL has a beneficial effect on metabolic disorder in relation to improved circulating insulin levels without affecting hepatic lipid metabolism-related gene expressions in rats.
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