Article

Circulating oxidized low-density lipoprotein and its association with carotid intima-media thickness in asymptomatic members of familial combined hyperlipidemia families.

Department of Medicine, Helsinki University Central Hospital, University of Helsinki, Finland.
Arteriosclerosis Thrombosis and Vascular Biology (impact factor: 6.37). 09/2004; 24(8):1492-7. DOI:10.1161/01.ATV.0000135982.60383.48 pp.1492-7
Source: PubMed

ABSTRACT Oxidized low-density lipoprotein (Ox-LDL)is implicated in the pathogenesis of atherosclerosis. Circulating oxidation-specific epitopes on plasma Ox-LDL has been linked with coronary artery disease, but its determinants and its association with early development of atherosclerosis in familial combined hyperlipidemia (FCHL) has not been very well studied. This study aimed to investigate the determinants of the circulating Ox-LDL and the association between Ox-LDL and carotid intima-media thickness (IMT) in asymptomatic members of FCHL families.
Ox-LDL, susceptibility of LDL to oxidation in vitro, plasma 8-isoprostane and antioxidants, lipids and lipoproteins, LDL particle size, and carotid IMT were measured in 150 asymptomatic FCHL family members. Affected FCHL family members had reduced LDL particle size and lag time for LDL oxidation, increased plasma levels of Ox-LDL, increased plasma urate and alpha-tocopherol, and a trend for the increase of 8-isoprostane as compared with nonaffected FCHL. Ox-LDL was independently associated with serum LDL cholesterol, apoB, and 8-isoprostane in multivariate analysis but only univariately correlated with LDL particle size and lag time for LDL oxidation. In addition, Ox-LDL was significantly associated with carotid mean IMT independently of other clinical and biochemical variables in a multivariate model.
Serum LDL cholesterol, apoB levels, and 8-isoprostane were the most important determinants of Ox-LDL. Ox-LDL is independently associated with carotid IMT in asymptomatic FCHL family members and can be used as a marker of early atherosclerosis in FCHL.

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Keywords

150 asymptomatic FCHL family members
 
Affected FCHL family members
 
apoB levels
 
asymptomatic FCHL family members
 
carotid intima-media thickness
 
circulating Ox-LDL
 
Circulating oxidation-specific epitopes
 
coronary artery disease
 
FCHL families
 
LDL oxidation
 
LDL particle size
 
lipoproteins
 
multivariate analysis
 
Ox-LDL
 
Ox-LDL)is
 
Oxidized low-density lipoprotein
 
plasma 8-isoprostane
 
plasma levels
 
plasma Ox-LDL
 
Serum LDL cholesterol