Article

Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight Homeostasis

Department of Medicine, Division of Endocrinology, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue RN, Boston, MA 02215, USA.
Neuron (Impact Factor: 15.98). 07/2004; 42(6):983-91. DOI: 10.1016/j.neuron.2004.06.004
Source: PubMed

ABSTRACT Neuroanatomical and electrophysiological studies have shown that hypothalamic POMC neurons are targets of the adipostatic hormone leptin. However, the physiological relevance of leptin signaling in these neurons has not yet been directly tested. Here, using the Cre/loxP system, we critically test the functional importance of leptin action on POMC neurons by deleting leptin receptors specifically from these cells in mice. Mice lacking leptin signaling in POMC neurons are mildly obese, hyperleptinemic, and have altered expression of hypothalamic neuropeptides. In summary, leptin receptors on POMC neurons are required but not solely responsible for leptin's regulation of body weight homeostasis.

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Available from: Robert A McGovern, Aug 15, 2014
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    • "Similarly, optogenetic activation of POMC neurons reduces food intake and body weight, whereas activation of AgRP evokes voracious feeding (Aponte et al., 2011). Accordingly, leptin and insulin receptor signaling in POMC or AgRP neurons is necessary for normal regulation of body weight and glucose homeostasis (Balthasar et al., 2004; Kitamura et al., 2006; van de Wall et al., 2008; Belgardt et al., 2008; Xu et al., 2007). "
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