Article

To learn better, keep the HAT on.

Department of Psychiatry and Beiobehavioral Sciences, Neuropsychiatric Institute, University of California, Los Angeles 90095, USA.
Neuron (Impact Factor: 15.98). 07/2004; 42(6):879-81. DOI: 10.1016/j.neuron.2004.06.007
Source: PubMed

ABSTRACT Long-lasting memories are known to require new transcription. Recent studies have highlighted a role for epigenetic alterations, including histone acetylation, in regulating gene expression. In this issue of Neuron, Alarcón et al. and Korzus et al. use two different mouse models of Rubinstein-Taybi syndrome to elucidate a role for the histone acetyltransferase activity of CREB binding protein (CBP) in long-term memory and plasticity.

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