Duration of diastole and its phases as a function of heart rate during supine bicycle exercise

Washington University in St. Louis, San Luis, Missouri, United States
AJP Heart and Circulatory Physiology (Impact Factor: 3.84). 12/2004; 287(5):H2003-8. DOI: 10.1152/ajpheart.00404.2004
Source: PubMed


The duration of diastole can be defined in terms of mechanical events. Mechanical diastolic duration (MDD) is comprised by the phases of early rapid filling (E wave), diastasis, and late atrial filling (A wave). The effect of heart rate (HR) on diastolic duration is predictable from kinematic modeling and known cellular physiology. To determine the dependence of MDD of each phase and the velocity time integral (VTI) on HR, simultaneous transmitral Doppler flow velocities and ECG were recorded during supine bicycle exercise in healthy volunteers. Durations, peak values, and VTI using triangular approximation for E- and A-wave shape were measured. MDD, defined as the interval from the start of the E wave to end of the A wave, was fit as an algebraic function of HR by MDD=BMDD + MLMDD.HR + MIMDD/HR, derivable from first principles, where BMDD is a constant, and MLMDD and MIMDD are the constant coefficients of the linear and inverse HR dependent terms. Excellent correlation was observed (r2=0.98). E- and A-wave durations were found to be very nearly independent of HR: 100% increase in HR generated only an 18% decrease in E-wave duration and 16% decrease in A-wave duration. VTI was similarly very nearly independent of HR. Diastasis duration closely tracked MDD as a function of HR. We conclude that the elimination of diastasis and merging of E and A waves of nearly fixed durations primarily govern changes in MDD. These observations support the perspective that E- and A-wave durations are primarily governed by the rules of mechanical oscillation that are minimally HR dependent.

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    • "It is during these phases that the maximum pressure rise and fall occurs in the left ventricle without any change in the volume together with the closing and opening of the mitral valve, respectively. The duration of each of these phases of a representative flow waveform have been modeled using published data [38] [39] as shown in Table 1 when the heart rate (HR) was chosen as 67bpm for a normal heart. "
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    ABSTRACT: The impact of surface trabeculae and papillary muscles on the hemodynamics of the left ventricle (LV) is investigated using numerical simulations. Simulations of ventricular flow are conducted for two different models of the LV derived from high-resolution cardiac computed tomography (CT) scans using an immersed boundary method-based flow solver. One model comprises a trabeculated left ventricle (TLV) that includes both trabeculae and papillary muscles, while the second model has a smooth left ventricle that is devoid of any of these surface features. Results indicate that the trabeculae and papillary muscles significantly disrupt the vortices that develop during early filling in the TLV model. Large recirculation zones are found to form in the wake of the papillary muscles; these zones enhance the blockage provided by the papillary muscles and create a path for the mitral jet to penetrate deeper into the ventricular apex during diastole. During systole, the trabeculae enhance the apical washout by ‘squeezing’ the flow from the apical region. Finally, the trabeculae enhance viscous dissipation rate of the ventricular flow, but this effect is not significant in the overall power budget.
    Theoretical and Computational Fluid Dynamics 05/2015; DOI:10.1007/s00162-015-0349-6 · 1.80 Impact Factor
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    • "Because left atrial pressure is not routinely recorded during cardiac catheterization P MVO very well approximated by LVEDP (Ishida et al. 1986; Murakami et al. 1986; Miki et al. 1991; Chung et al. 2004 "
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    ABSTRACT: Although catheterization is the gold standard, Doppler echocardiography is the preferred diastolic function (DF) characterization method. The physiology of diastole requires continuity of left ventricular pressure (LVP)‐generating forces before and after mitral valve opening (MVO). Correlations between isovolumic relaxation (IVR) indexes such as tau (time‐constant of IVR) and noninvasive, Doppler E‐wave‐derived metrics, such as peak A‐V gradient or deceleration time (DT), have been established. However, what has been missing is the model‐predicted causal link that connects isovolumic relaxation (IVR) to suction‐initiated filling (E‐wave). The physiology requires that model‐predicted terminal force of IVR (Ft IVR) and model‐predicted initial force of early rapid filling (Fi E‐wave) after MVO be correlated. For validation, simultaneous (conductance catheter) P‐V and E‐wave data from 20 subjects (mean age 57 years, 13 men) having normal LV ejection fraction (LVEF>50%) and a physiologic range of LV end‐diastolic pressure (LVEDP) were analyzed. For each cardiac cycle, the previously validated kinematic (Chung) model for isovolumic pressure decay and the Parametrized Diastolic Filling (PDF) kinematic model for the subsequent E‐wave provided Ft IVR and Fi E‐wave respectively. For all 20 subjects (15 beats/subject, 308 beats), linear regression yielded Ft IVR= α Fi E‐wave + b (R = 0.80), where α = 1.62 and b = 1.32. We conclude that model‐based analysis of IVR and of the E‐wave elucidates DF mechanisms common to both. The observed in vivo relationship provides novel insight into diastole itself and the model‐based causal mechanistic relationship that couples IVR to early rapid filling.
    03/2014; 2(3). DOI:10.1002/phy2.258
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    • "The length of diastasis in diastole with less motion velocity was evaluated integrating the ECG signal. The end of the E-wave corresponded to the onset of diastasis (a), and the beginning of the late diastolic filling peak velocity (A-wave) corresponded to the end of diastasis (b) [18]. All data were recorded using the absolute timing (ms) from the previous R-peak. "
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    ABSTRACT: As Doppler ultrasound has been proven to be an effective tool to predict and compress the optimal pulsing windows, we evaluated the effective dose and diagnostic accuracy of coronary CT angiography (CTA) incorporating Doppler-guided prospective electrocardiograph (ECG) gating, which presets pulsing windows according to Doppler analysis, in patients with a heart rate >65 bpm. 119 patients with a heart rate >65 bpm who were scheduled for invasive coronary angiography were prospectively studied, and patients were randomly divided into traditional prospective (n = 61) and Doppler-guided prospective (n = 58) ECG gating groups. The exposure window of traditional prospective ECG gating was set at 30%-80% of the cardiac cycle. For the Doppler group, the length of diastasis was analyzed by Doppler. For lengths greater than 90 ms, the pulsing window was preset during diastole (during 60%-80%); otherwise, the optimal pulsing intervals were moved from diastole to systole (during 30%-50%). The mean heart rates of the traditional ECG and the Doppler-guided group during CT scanning were 75.0±7.7 bpm (range, 66-96 bpm) and 76.5±5.4 bpm (range: 66-105 bpm), respectively. The results indicated that whereas the image quality showed no significant difference between the traditional and Doppler groups (P = 0.42), the radiation dose of the Doppler group was significantly lower than that of the traditional group (5.2±3.4mSv vs. 9.3±4.5mSv, P<0.001). The sensitivities of CTA applying traditional and Doppler-guided prospective ECG gating to diagnose stenosis on a segment level were 95.5% and 94.3%, respectively; specificities 98.0% and 97.1%, respectively; positive predictive values 90.7% and 88.2%, respectively; negative predictive values 99.0% and 98.7%, respectively. There was no statistical difference in concordance between the traditional and Doppler groups (P = 0.22). Doppler-guided prospective ECG gating represents an improved method in patients with a high heart rate to reduce effective radiation doses, while maintaining high diagnostic accuracy.
    PLoS ONE 05/2013; 8(5):e63096. DOI:10.1371/journal.pone.0063096 · 3.23 Impact Factor
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