Social facilitation of wound healing

Department of Psychology, The Ohio State University, 01 Townsend Hall, 1885 Neil Avenue, Columbus, OH 43210 USA.
Psychoneuroendocrinology (Impact Factor: 4.94). 10/2004; 29(8):1004-11. DOI: 10.1016/j.psyneuen.2003.10.003
Source: PubMed


It is well documented that psychological stress impairs wound healing in humans and rodents. However, most research effort into influences on wound healing has focused on factors that compromise, rather than promote, healing. In the present study, we determined if positive social interaction, which influences hypothalamic-pituitary-adrenal (HPA) axis activity in social rodents, promotes wound healing. Siberian hamsters received a cutaneous wound and then were exposed to immobilization stress. Stress increased cortisol concentrations and impaired wound healing in isolated, but not socially housed, hamsters. Removal of endogenous cortisol via adrenalectomy eliminated the effects of stress on wound healing in isolated hamsters. Treatment of isolated hamsters with oxytocin (OT), a hormone released during social contact and associated with social bonding, also blocked stress-induced increases in cortisol concentrations and facilitated wound healing. In contrast, treating socially housed hamsters with an OT antagonist delayed wound healing. Taken together, these data suggest that social interactions buffer against stress and promote wound healing through a mechanism that involves OT-induced suppression of the HPA axis. The data imply that social isolation impairs wound healing, whereas OT treatment may ameliorate some effects of social isolation on health.

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Available from: Erica R Glasper, Oct 07, 2015
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    • "Lizard (McCormick and Langkilde, 2014) Squirrel (Brooks and Mateo, 2013) Squirrel (Brooks and Mateo, 2013) Hemag., DTH, Antibody Resp. Antibody response Chicken (El-Lethey et al., 2003) Chicken (El-Lethey et al., 2003) Handling BKA Wound Healing Fish (Eslamloo et al., 2014) Lizard (French et al., 2006) Hamster (Detillion et al., 2004) Hemag. "
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    • "Relative to isolated individuals, socially housed female Siberian hamsters experience improved wound healing; an effect which is mediated by oxytocin (Detillion et al., 2004). While little is known about the natural social organization of this hamster species (Wynne-Edwards and Lisk, 1989), wound healing has also been studied in three species of Peromyscus mice for which social organization is well characterized. "
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