Practical Algorithms in Anemia Diagnosis

Mayo Clinic Proceedings (Impact Factor: 6.26). 08/2004; 79(7):955-6. DOI: 10.1016/S0025-6196(11)62173-3
Source: PubMed
19 Reads
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: A complete blood cell count (CBC) is one of the most common laboratory tests in medicine. For example, at our institution alone, approximately 1800 CBCs are ordered every day, and 10% to 20% of results are reported as abnormal. Therefore, it is in every clinician's interest to have some understanding of the specific test basics as well as a structured action plan when confronted with abnormal CBC results. In this article, we provide practical diagnostic algorithms that address frequently encountered conditions associated with CBC abnormalities including anemia, thrombocytopenia, leukopenia, polycythemia, thrombocytosis, and leukocytosis. The objective is to help the nonhematologist recognize when a subspecialty consultation is reasonable and when it may be circumvented, thus allowing a cost-effective and intellectually rewarding practice.
    Mayo Clinic Proceedings 08/2005; 80(7):923-36. DOI:10.4065/80.7.923 · 6.26 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Anemia signifies an underlying disease and is associated with poor clinical outcomes. In elderly patients, in whom anemia has a high prevalence (greater than 10 percent), neither the hemoglobin threshold for concern nor the identity of the anemia-causing disease is easily established. This is an important shortfall, because even mild anemia can compromise patient well-being and survival, regardless of the underlying cause. This review discusses definitions of "normal" hemoglobin levels in adults, common causes of anemia in people aged 65 years and older (eg, nutritional deficiency, renal insufficiency, inflammatory disorders, and myelodysplastic syndrome), and potential consequences of anemia in elderly patients (eg, poorer cognitive status, increased frailty, and an elevated risk of hospitalization and of complications during hospitalization). We also outline a practical initial diagnostic approach that helps determine appropriate treatment, and we weigh therapeutic options in light of new safety concerns regarding erythropoiesis-stimulating agents.
    Mayo Clinic Proceedings 09/2007; 82(8):958-66. DOI:10.4065/82.8.958 · 6.26 Impact Factor
  • 11/2008; 10(20). DOI:10.1016/S0211-3449(08)75384-0
Show more