Article

Breast cancer in Iran: a survival analysis

Iranian Institute for Health Sciences Research, Tehran, Iran.
Asian Pacific journal of cancer prevention: APJCP (Impact Factor: 2.51). 11/2003; 5(2):223-5.
Source: PubMed

ABSTRACT A prospective study was undertaken to examine survival in Iranian breast cancer patients. One hundred and sixty-seven breast cancer patients diagnosed in 1997 were entered into the study and followed up for five years. The mean age of the patients at diagnosis was 47.2 (SD = 13.5), ranging from 24 to 81 years. A total of 39 patients were lost in the follow-up period, leaving 128 for analysis of data. Of these, 79 were alive and 49 were dead after five years. Most patients (61%) presented with advanced disease. Using life table analysis, the overall relative 5-year survival rate was found to be 62% (SE = 0.04). In addition, after adjustment for age at diagnosis, initial treatment (mastectomy, breast conserving surgery, and neo-adjuvant therapy), and disease stage, using Cox's regression model, it was found that receiving neo-adjuvant therapy as the initial treatment was an independent predictor of poorer survival (Hazard ratio = 4.56, 95% CI 2.20-9.44, P<0.0001). The other variables (older age and late stage disease), although associated with high hazards rates, were not significant. The study findings suggest that overall relative survival rate in Iranian breast cancer patients stands between western and eastern European countries and needs to be improved. It seems that early detection and better management using standard guidelines might contribute considerably to improvement of survival in women experiencing breast cancer.

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    • "This may be correspond with inclusion of higher number of patients in our study compared to cross sectional study of Ardabil (only patients of year 2003), as well as health promotion during the previous years. The other studies from Tehran have previously reported 5-year overall breast cancer survival rates of 60% (Mousavi et al., 2011) and 62% (Vahdaninia et al., 2004). These studies were conducted on records of patients during 1998-2001 and 1997 respectively. "
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    Asian Pacific journal of cancer prevention: APJCP 01/2013; 14(1):39-42. DOI:10.7314/APJCP.2013.14.1.39 · 2.51 Impact Factor
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    • "Despite significant individual effect of each parameter on RER, their effect became nonsignificant in multivariate analysis. Similar nonsignificant effect of tumour stage on breast cancer outcome, either recurrence or death, has been reported by two studies with smaller sample size conducted in Iran [22] [33]. "
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    • "In the current study, the mean age of all the patients was 47.88±10.98 years, which is consistent with the reported results (Vahdaninia & Montazeri, 2004; Mousavi et al. ,2006), and proves that the onset of breast cancer in Iranian women is a decade earlier, when compared with those in Western countries (Harirchi et al., 2000; Mousavi et al., 2007b; Kolahdoozan et al., 2010). However, a significant correlation and an increasing trend of methylation were found for ER5 in elder patients than the younger ones. "
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