Breast cancer in Iran: A survival analysis

Iranian Institute for Health Sciences Research, Tehran, Iran.
Asian Pacific journal of cancer prevention: APJCP (Impact Factor: 2.51). 11/2003; 5(2):223-5.
Source: PubMed


A prospective study was undertaken to examine survival in Iranian breast cancer patients. One hundred and sixty-seven breast cancer patients diagnosed in 1997 were entered into the study and followed up for five years. The mean age of the patients at diagnosis was 47.2 (SD = 13.5), ranging from 24 to 81 years. A total of 39 patients were lost in the follow-up period, leaving 128 for analysis of data. Of these, 79 were alive and 49 were dead after five years. Most patients (61%) presented with advanced disease. Using life table analysis, the overall relative 5-year survival rate was found to be 62% (SE = 0.04). In addition, after adjustment for age at diagnosis, initial treatment (mastectomy, breast conserving surgery, and neo-adjuvant therapy), and disease stage, using Cox's regression model, it was found that receiving neo-adjuvant therapy as the initial treatment was an independent predictor of poorer survival (Hazard ratio = 4.56, 95% CI 2.20-9.44, P<0.0001). The other variables (older age and late stage disease), although associated with high hazards rates, were not significant. The study findings suggest that overall relative survival rate in Iranian breast cancer patients stands between western and eastern European countries and needs to be improved. It seems that early detection and better management using standard guidelines might contribute considerably to improvement of survival in women experiencing breast cancer.

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Available from: Mariam Vahdaninia,
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    • "This may be correspond with inclusion of higher number of patients in our study compared to cross sectional study of Ardabil (only patients of year 2003), as well as health promotion during the previous years. The other studies from Tehran have previously reported 5-year overall breast cancer survival rates of 60% (Mousavi et al., 2011) and 62% (Vahdaninia et al., 2004). These studies were conducted on records of patients during 1998-2001 and 1997 respectively. "
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    • "This cancer affects Iranian women at least one decade younger than their counterparts in developed countries (6).The mortality rate of breast cancer was 5.8 per 100,000 women in Tehran in 1998 (7), 2.5 per 100,000 for female population. Estimation of five-year survival is one of the indicators used to evaluate the quality of care for different types of malignancies. "
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    • "Despite significant individual effect of each parameter on RER, their effect became nonsignificant in multivariate analysis. Similar nonsignificant effect of tumour stage on breast cancer outcome, either recurrence or death, has been reported by two studies with smaller sample size conducted in Iran [22] [33]. "
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