Article

Synergic activity of selenium and probiotic bacterium Enterococcus faecium M-74 against selected mutagens in Salmonella assay.

Institute of Cell Biology, Faculty of Science, Comenius University, 811 07 Bratislava, Slovakia.
Folia Microbiologica (Impact Factor: 1.15). 02/2004; 49(3):301-5. DOI: 10.1007/BF02931047
Source: PubMed

ABSTRACT Concentrated extracts of MRS (De Man-Rogosa-Sharpe) media in which probiotic bacterium Enterococcus faecium strain M-74 was grown exerted different antimutagenic activity against ofloxacin-, N-methyl, N'-nitro-N-nitrosoguanidine- and sodium 5-nitro-2-furylacrylate-induced mutagenicity in Salmonella typhimurium assay depending on the presence (+Se) or absence of disodium selenite pentahydrate (-Se). The antimutagenicity of MRS(+Se) extract was higher than that of MRS(-Se) extract. Selenium enhanced also the antimutagenic effect of both live and killed cells of E. faecium M-74, respectively. The live bacteria decreased the mutagenicity of selected substances more than killed cells. Synergic activity of selenium with the bacterium was also manifested.

0 Bookmarks
 · 
56 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Selenium, an essential trace element, is transformed from inorganic to organic and elemental forms by many lactic acid bacteria. This feature is now being considered for potentiating various technological properties of these cultures as well as for delivering a number of nutritive, safe and more bioavailable selenium compounds like selenocysteine, selenomethionine and methylated selenium species for human and animal nutrition. Selenium-enriched probiotics have been shown to confer several health benefits on the host for their antioxidative, antipathogenic, antimutagenic, anticarcinogenic and anti-inflammatory activities. Here, we review currently available information on selenium enrichment of LAB and its nutritional, health and technological implications for designing novel functional foods.
    Trends in Food Science & Technology 07/2014; DOI:10.1016/j.tifs.2014.07.006 · 4.65 Impact Factor
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Selenium (Se) is an essential trace element for humans, plants and microorganisms. Inorganic selenium is present in nature in four oxidation states: selenate, selenite, elemental Se and selenide in decreasing order of redox status. These forms are converted by all biological systems into more bioavailable organic forms, mainly as the two seleno-amino acids selenocysteine and selenomethionine. Humans, plants and microorganisms are able to fix twhese amino acids into proteins originating Se-containing proteins by a simple replacement of methionine with selenomethionine, or "true" selenoproteins if the insertion of selenocysteine is genetically encoded by a specific UGA codon. Selenocysteine is usually present in the active site of enzymes, being essential for their catalytic activity. This review will focus on the strategies adopted by the different biological systems for selenium incorporation into proteins and on the importance of this element for the physiological functions of living organisms. The most known selenoproteins of humans and microorganisms will be listed highlighting the importance of this element and the problems connected with its deficiency.
    Current Protein and Peptide Science 06/2014; DOI:10.2174/1389203715666140608151134 · 2.33 Impact Factor
  • Source
    International Journal of Probiotics and Prebiotics 01/2011; 6(3/4):179-186.