Concentrated extracts of MRS (De Man-Rogosa-Sharpe) media in which probiotic bacterium Enterococcus faecium strain M-74 was grown exerted different antimutagenic activity against ofloxacin-, N-methyl, N'-nitro-N-nitrosoguanidine- and sodium 5-nitro-2-furylacrylate-induced mutagenicity in Salmonella typhimurium assay depending on the presence (+Se) or absence of disodium selenite pentahydrate (-Se). The antimutagenicity of MRS(+Se) extract was higher than that of MRS(-Se) extract. Selenium enhanced also the antimutagenic effect of both live and killed cells of E. faecium M-74, respectively. The live bacteria decreased the mutagenicity of selected substances more than killed cells. Synergic activity of selenium with the bacterium was also manifested.
"Se-enriched probiotic combination (Ren et al., 2011) Se-enriched probiotic combination (Yang et al., 2009) Se-enriched Sauerkraut (Pe~ nas et al., 2012) 5 Antimutagenic Se-enriched E. faecium 74 (Kri zkov a et al., 2002) Se-enriched E. faecium 74 (Belicov a et al., 2004) 6 Anticarcinogenic activity Se-enriched B. longum (Yin et al., 2011) Se-enriched B. longum (Wang et al., 2011) Se-enriched Lb. plantarum (Yazdi, Mahdavi, Kheradmand, et al., 2012) Se-enriched Lb. brevis (Yazdi, Mahdavi, et al., 2013) 7 Modulation of gut microflora Se-enriched probiotic combination (Ren et al., 2011) 8 Improved male fertility Se-enriched probiotic combination (Ibrahim et al., 2012) 9 Hypocholesterolemic effect Se-enriched E. faecium 74 (Hlivak et al., 2005) 10 Anti-inflammatory activity Se-enriched Sauerkraut (Pe~ nas et al., 2012) the production of proinflammatory cytokines like IFN-g, TNF-a, and IL-2 in mice bearing breast cancer, suggesting improved immune response during cancer prognosis. Selenium supplementation, thus presents a promising approach for enhancing the antimutagenic and anticarcinogenic potential of probiotics. "
[Show abstract][Hide abstract] ABSTRACT: Selenium, an essential trace element, is transformed from inorganic to organic and elemental forms by many lactic acid bacteria. This feature is now being considered for potentiating various technological properties of these cultures as well as for delivering a number of nutritive, safe and more bioavailable selenium compounds like selenocysteine, selenomethionine and methylated selenium species for human and animal nutrition. Selenium-enriched probiotics have been shown to confer several health benefits on the host for their antioxidative, antipathogenic, antimutagenic, anticarcinogenic and anti-inflammatory activities. Here, we review currently available information on selenium enrichment of LAB and its nutritional, health and technological implications for designing novel functional foods.
"Several studies have showed that fermented dairy products and/or probiotic bacteria posses desmutagenic properties, with the activity increasing with increasing numbers of viable cells (Belicova et al., 2004; Caldini et al., 2005; Chalova et al., 2008; Thyagaraja and Hosono, 1994; Usman and Hosono, 1998). "
[Show abstract][Hide abstract] ABSTRACT: The aim of the present study was to investigate the impact of a probiotic product commercially distributed, consisting of a mix of four different species of Bifidobacterium [i.e. (B. bifidum, B. breve, B. longum, B. infantis) (Bifiselle)], on the DNA-damaging effects of 2-amino-l-methyl-6-phenylimidazo[4, 5-b]pyridine (PhIP) or acrylamide. Male CD1 mice were treated orally with PhIP or acrylamide. Suspensions of bifidobacteria were given by gavage to the animals 3 h before administration of model genotoxins. Subsequently, the extent of DNA migration was measured in colon and liver cells by the single-cell microgelelectrophoresis (comet) assay. The Bifidobacterium strains mix suspension caused a significant inhibition of DNA damage induced by PhIP in the colon and by acrylamide in the liver.
International Journal of Probiotics and Prebiotics 01/2011; 6(3/4):179-186.
"The strains survived in the presence of even 5 % Oxgall which corresponds to very high bile resistance and good survival ability in the digestive tract of animals. In comparison, Strompfová et al. (2004b) reported enterococci isolated from canine feces that tolerated 1 % bile. Urease activity is one of metabolic enterococcal properties. Enterococci isolated from ruminants, in particular, represent strains with urease activity (Lauková and Koniarová 1995). However, based on our previous results, enterococci from other sources, e.g., env"
[Show abstract][Hide abstract] ABSTRACT: Enterococci isolated from 28 different commercially available feeds (10-1000 CFU/mL) were identified and their probiotic potential was determined. Species identification of 22 selected strains was performed by intergenic length-polymorphism analysis (tRNA-PCR); PCR products were analyzed using capillary electrophoresis. Six strains were allotted to the species Enterococcus faecium, four to E. faecalis, one to E. hirae; the remaining strains were not classed. The strains were sensitive to vancomycin, ampicillin, tetracycline and rifampicin. They were able to adhere to human as well as canine intestinal mucus. They produced lactic acid (0.99-1.04 mmol/L) and most of them were urease-positive with sufficient survival in 5 % Oxgall-bile. They did not show any inhibitory activity due to antimicrobial substances. Plasmid DNA was detected in 8 strains, the bands responding to small molecular size (10 kbp). Considering all probiotically important properties, E. faecium strain EE3 was suggested as potential feed additive.
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