Emergence in Italy of a Neisseria meningitidis clone with decreased susceptibility to penicillin.

Department of Infectious, Parasitic & Immuno-mediated Diseases, Istituto Superiore di Sanita', Rome, Italy.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.57). 09/2004; 48(8):3103-6. DOI: 10.1128/AAC.48.8.3103-3106.2004
Source: PubMed

ABSTRACT A rise in invasive diseases due to Neisseria meningitidis C:2b:P1.5 with decreased penicillin susceptibility occurred in Italy during the last 2 years. Real-time PCR identified the Peni phenotype, and the penA sequence revealed the mosaicism of the gene. Molecular analyses assigned the isolates to a single emergent clone of the hypervirulent A4 cluster.

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