Changes in serum leptin concentrations in overweight Japanese men after exercise
ABSTRACT To investigate the link between serum leptin concentrations and exercise.
Cross-sectional and longitudinal studies of an exercise intervention.
110 Japanese overweight men aged 32-59 years were recruited. At baseline, the average body mass index (BMI) was 28.5 +/- 2.5 kg/m2. From this group, we used data of 36 overweight men (BMI, 28.9 +/- 2.3) for a 1-year exercise programme.
Leptin was measured at baseline and after 1 year. Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography (CT) scanning at umbilical levels. Anthropometric parameters, aerobic exercise level, muscle strength and flexibility were also investigated at baseline and after 1 year.
In the first analysis, using cross-sectional data, leptin was significantly correlated with total body fat (r = 0.760, p < 0.01), V (r = 0.383, p < 0.01) and S (r = 0.617, p < 0.01) areas. In the second analysis, using longitudinal data, leptin was significantly reduced after 1 year (pre 6.7 +/- 4.0 ng/ml vs. post 5.1 +/- 3.1 ng/ml, p < 0.01). Results showed that steps per day were increased, and aerobic exercise level, weight-bearing index (WBI) and insulin resistance were significantly improved. Although, there was a positive correlation between Delta leptin(positive changes in leptin after 1 year) and anthropometric measurements such as Delta body weight, Delta BMI and Delta body fat, leptin/body weight, leptin/BMI and leptin/body fat ratios were significantly reduced during exercise intervention.
The present study indicated exercise significantly lowers serum leptin concentrations, and thus it may improve the leptin resistance observed in overweight Japanese men.
SourceAvailable from: Motohiko Miyachi[Show abstract] [Hide abstract]
ABSTRACT: The aim of this study was to evaluate the link between circulating leptin levels and physical activity and/or physical fitness in apparently healthy Japanese.Environmental Health and Preventive Medicine 07/2014; 19(5). DOI:10.1007/s12199-014-0398-2
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ABSTRACT: Physical activity is a well-known modifiable lifestyle means for reducing postmenopausal disease risks, but the relevant biological mechanisms are not well-understood. Metabolic factors may be involved. Purpose: In this study, we aimed at determining the effects of 8weeks of an aerobic training program on plasma levels of adiponectin and leptin in Postmenopausal middle-aged Women. Material and Methods: For this purpose, twenty middle-aged healthy Women were selected and assigned to two equal groups of experimental and control, based on their body fat percentage. The experimental group participated in 8weeks of aerobic training, 4 days a week in alteration days, at the 65-75 percent of maximum heart rate, but the control group remained sedentary. Blood samples were collected prior to and after the training program for all subjects and plasma adipokines levels were measured. Results: Results showed a decrease in leptin concentrations, and a significant increase in adiponectin concentrations, following 8weeks of the aerobic training program (p<0.001). In addition, reduction of body fat percentage (p<0.001) negatively correlated with adiponectin (p<0.001) but positively correlated with leptin changes (p<0.001). Discussion and Conclusion: In postmenopausal middle-aged women, 8weeks of aerobic training reduced body fat percentage and improved plasma adipokines levels, so aerobic training can be considered as an effective way for preventing obesity and associated diseases.
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ABSTRACT: We investigated the relationship among delta (delta represents changes in parameters) vis-ceral fat area, waist circumference and body weight in Japanese freshmen students. Visceral fat was measured at the umbilical level using computerized tomography scanning at baseline study and 6 months later. Body weight and height, as well as waist circumference were also measured. We found that visceral fat area, waist circumference, and body weight significantly correlated with each other at baseline, and 6 months later, delta visceral fat area and changes in % visceral fat area significantly correlated with delta waist circumference and delta body weight in female and in total subjects. In addi-tion, based on the predictive linear equations from the regression analysis, we found that 1kg of delta body weight corresponded to 0.83 cm of delta waist circumference, and 1kg of delta body weight and 1cm of delta waist circumference corresponded to 9.41% and 7.80% of changes in visceral fat area, respectively, in total subjects. The present results suggest that delta visceral fat area is closely related to delta body weight and delta waist circumference in Japanese freshmen students.