Changes in serum leptin concentrations in overweight Japanese men after exercise

Department of Public Health, Okayama University, Okayama, Okayama, Japan
Diabetes Obesity and Metabolism (Impact Factor: 6.36). 10/2004; 6(5):332-7. DOI: 10.1111/j.1462-8902.2004.00351.x
Source: PubMed


To investigate the link between serum leptin concentrations and exercise.
Cross-sectional and longitudinal studies of an exercise intervention.
110 Japanese overweight men aged 32-59 years were recruited. At baseline, the average body mass index (BMI) was 28.5 +/- 2.5 kg/m2. From this group, we used data of 36 overweight men (BMI, 28.9 +/- 2.3) for a 1-year exercise programme.
Leptin was measured at baseline and after 1 year. Fat distribution was evaluated by visceral fat (V) and subcutaneous fat (S) areas measured with computed tomography (CT) scanning at umbilical levels. Anthropometric parameters, aerobic exercise level, muscle strength and flexibility were also investigated at baseline and after 1 year.
In the first analysis, using cross-sectional data, leptin was significantly correlated with total body fat (r = 0.760, p < 0.01), V (r = 0.383, p < 0.01) and S (r = 0.617, p < 0.01) areas. In the second analysis, using longitudinal data, leptin was significantly reduced after 1 year (pre 6.7 +/- 4.0 ng/ml vs. post 5.1 +/- 3.1 ng/ml, p < 0.01). Results showed that steps per day were increased, and aerobic exercise level, weight-bearing index (WBI) and insulin resistance were significantly improved. Although, there was a positive correlation between Delta leptin(positive changes in leptin after 1 year) and anthropometric measurements such as Delta body weight, Delta BMI and Delta body fat, leptin/body weight, leptin/BMI and leptin/body fat ratios were significantly reduced during exercise intervention.
The present study indicated exercise significantly lowers serum leptin concentrations, and thus it may improve the leptin resistance observed in overweight Japanese men.

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    • "exercise sessions had no effect on the expression of mRNA for leptin in subcutaneous WAT (Table 1) [32]. On the other hand, there have been many studies on the effects of TR on the human blood levels of leptin (Table 2) [34] [35] [36] [37] [38] [39] [40] [41] [42] [43] [44] [45] [46] [47] [48] [49] [50]. Many cases have shown that concentrations of leptin decrease a reduction in WAT mass (Table 2) [34, 36, 41–45, 47, 48]. "
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    ABSTRACT: Obesity is recognized as a risk factor for lifestyle-related diseases such as type 2 diabetes and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for energy; it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors, such as leptin and adiponectin, which are collectively referred to as adipokines. Additionally, because there is much evidence that obesity-induced inflammatory changes in WAT, which is caused by dysregulated expression of inflammation-related adipokines involving tumor necrosis factor- α and monocyte chemoattractant protein 1, contribute to the development of insulin resistance, WAT has attracted special attention as an organ that causes diabetes and other lifestyle-related diseases. Exercise training (TR) not only leads to a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the inflammation-related adipokines in WAT. Therefore, TR is widely used as a tool for preventing and improving lifestyle-related diseases. This review outlines the impact of TR on the expression and secretory response of adipokines in WAT.
    International Journal of Endocrinology 12/2013; 2013(3):801743. DOI:10.1155/2013/801743 · 1.95 Impact Factor
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    • "The majority of studies have reported either no change31,94–96 or a reduction in leptin levels97–102 after chronic exercise training, and these results have been attributed primarily to the capacity of exercise to induce a loss of fat mass.97,98,100,102 Conversely, a few studies have demonstrated a reduction in leptin levels and/or expression regardless of any changes in adiposity.99,101 These results suggest that there may be factors beyond adiposity that regulate leptin levels and expression after endurance training, among which adipokines are strong candidates. "
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    Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 04/2011; 4:141-54. DOI:10.2147/DMSO.S12143
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    ABSTRACT: Physical activity is a well-known modifiable lifestyle means for reducing postmenopausal disease risks, but the relevant biological mechanisms are not well-understood. Metabolic factors may be involved. Purpose: In this study, we aimed at determining the effects of 8weeks of an aerobic training program on plasma levels of adiponectin and leptin in Postmenopausal middle-aged Women. Material and Methods: For this purpose, twenty middle-aged healthy Women were selected and assigned to two equal groups of experimental and control, based on their body fat percentage. The experimental group participated in 8weeks of aerobic training, 4 days a week in alteration days, at the 65-75 percent of maximum heart rate, but the control group remained sedentary. Blood samples were collected prior to and after the training program for all subjects and plasma adipokines levels were measured. Results: Results showed a decrease in leptin concentrations, and a significant increase in adiponectin concentrations, following 8weeks of the aerobic training program (p<0.001). In addition, reduction of body fat percentage (p<0.001) negatively correlated with adiponectin (p<0.001) but positively correlated with leptin changes (p<0.001). Discussion and Conclusion: In postmenopausal middle-aged women, 8weeks of aerobic training reduced body fat percentage and improved plasma adipokines levels, so aerobic training can be considered as an effective way for preventing obesity and associated diseases.
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