Characteristics of acoustic scattering from a double-layered micro shell for encapsulated drug delivery

Institute of Mechanics and Sensing Technology, Central South University, Changsha 410083, Hunan, China.
IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control (Impact Factor: 1.51). 08/2004; 51(7):809-21. DOI: 10.1109/TUFFC.2004.1320740
Source: PubMed


This work examines the characteristic differences in acoustic scattering between air-filled double-layered encapsulating (DLE) shells and air-filled single-layered encapsulating (SLE) shells. The analysis shows that the presence of an outer layer softer than the inner layer results in a shift of the first monopole of the reflectivity-frequency response to a higher frequency and a reduction in the monopole peak; and it leads to a frequency-separation of the two dipoles that trace the monopole. The frequency shift and the peak reduction of the monopole and the frequency separation of the two dipoles all increase with the increasing thickness of the softer outer layer. The numerical results reveal that variations in the Lame constant of the model material for the protein albumin have little effect on the low-frequency scattering characteristics, while they affect the high-frequency scattering characteristics significantly. The authors have shown that this phenomenon is due to the fact that the model material for the protein albumin has a Lame constant substantially larger than its shear modulus. Their further numerical studies conclude that, for each DLE shell, one can construct an equivalent SLE shell, using a simple scheme originated from the mechanics of composite materials in the sense that the so-constructed SLE shell has essentially the same acoustic scattering characteristics as the DLE shell within a low frequency range.

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    • "The encapsulated microbubbles for drug delivery usually have radii from 0.5 to 5μm with a shell-thickness between 10 and 250 nm and hence behave much like gas bubbles. There have been numerous theoretical investigations on the acoustic scattering and the nonlinear dynamics of UCAs in blood (Church 1995; Frinking et al. 1999; Allen et al. 2001; Allen et al. 2002; Hu et al. 2004; Stride and Saffari 2004; Qin et al. 2006). "
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    Physics in Medicine and Biology 11/2006; 51(20):5065-88. DOI:10.1088/0031-9155/51/20/001 · 2.76 Impact Factor
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    • "Eventually, they might even allow ultrasound to replace much of contemporary and future radionuclide imaging for functional studies, thus avoiding the problems associated with radioactivity, and with relatively high spatial and temporal resolutions. For further information, refer to Bekeredian et al (2002), Chomas et al (2001), Hope Simpson et al (1999, 2001), Hu et al (2004), Hughes et al (2003), Kvikliene et al (2004) and Stride and Saffari (2004) "
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