J. Age-related changes in plasma coenzyme Q10 concentrations and redox state in apparently healthy children and adults

Department of Mathematical Sciences, University of Cincinnati, Cincinnati, Ohio, United States
Clinica Chimica Acta (Impact Factor: 2.82). 10/2004; 347(1-2):139-44. DOI: 10.1016/j.cccn.2004.04.003
Source: PubMed


Coenzyme Q10 (CoQ) is an endogenous enzyme cofactor, which may provide protective benefits as an antioxidant. Because age-related CoQ changes and deficiency states have been described, there is a need to establish normal ranges in healthy children. The objectives of this study are to determine if age-related differences in reduced CoQ (ubiquinol), oxidized CoQ (ubiquinone), and CoQ redox state exist in childhood, and to establish reference intervals for these analytes in healthy children.
Apparently healthy children (n=68) were selected from individuals with no history of current acute illness, medically diagnosed disease, or current medication treatment. Self-reported healthy adults (n=106) were selected from the ongoing Princeton Follow-up Study in greater Cincinnati. Participants were assessed for lipid profiles, ubiquinol concentration, ubiquinone concentration, total CoQ concentration, and CoQ redox ratio.
Mean total CoQ and ubiquinol concentrations are similar in younger children (0.2-7.6 years) and adults (29-78 years); however, lipid-adjusted total CoQ concentrations are significantly increased in younger children. Also CoQ redox ratio is significantly increased in younger and older children compared with adults.
Elevated CoQ and redox ratios in children may be an indication of oxidative stress effects, which are associated with early development of coronary heart disease.

Download full-text


Available from: Peter Tang,
  • Source
    • "Maintaining adequate Co-Q10 level throughout the body is important for normal function and health. Plasma concentrations of Co-Q10 are high in healthy infant and children and declining with age [34,35]. Metabolic disorder may arise due to Co-Q10 deficiency. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Co-enzyme Q10 (Co-Q10) is an essential component of the mitochondrial electron transport chain. Most cells are sensitive to co-enzyme Q10 (Co-Q10) deficiency. This deficiency has been implicated in several clinical disorders such as heart failure, hypertension, Parkinson’s disease and obesity. The lipid lowering drug statin inhibits conversion of HMG-CoA to mevalonate and lowers plasma Co-Q10 concentrations. However, supplementation with Co-Q10 improves the pathophysiological condition of statin therapy. Recent evidence suggests that Co-Q10 supplementation may be useful for the treatment of obesity, oxidative stress and the inflammatory process in metabolic syndrome. The anti-inflammatory response and lipid metabolizing effect of Co-Q10 is probably mediated by transcriptional regulation of inflammation and lipid metabolism. This paper reviews the evidence showing beneficial role of Co-Q10 supplementation and its potential mechanism of action on contributing factors of metabolic and cardiovascular complications.
    Journal of Diabetes and Metabolic Disorders 05/2014; 13:60. DOI:10.1186/2251-6581-13-60
  • Source
    • "A comparison of the ubiquinol-10/ubiquinone- 10-ratio between children and adults shows that the quotient of the ratio decreases with increasing age. Additionally, absolute ubiquinone-10 levels are higher in younger children and adults than in older children [33]. Likewise, in a pediatric human study by Menke et al. it is depicted that redox-state (percentage of ubiquinone-10 in total CoQ 10 ) is higher in infants and pre-schoolers than in older children [31]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Coenzyme Q derivatives (CoQ) are lipid soluble antioxidants that are synthesized endogenously in almost all species and function as an obligatory cofactor of the respiratory chain. There is evidence that CoQ status is altered by age in several species. Here we determined level and redox-state of CoQ in different age groups of pigs, mice and Caenorhabditis elegans. Since these species are very different with respect to lifespan, reproduction and physiology, our approach could provide some general tendencies of CoQ status in ageing organisms. We found that CoQ level decreases with age in pigs and mice, whereas CoQ content increases in older worms. As observed in all three species, ubiquinone, the oxidized form of CoQ, increases with age. Additionally, we were able to show that supplementation of ubiquinol-10, the reduced form of human CoQ10 , slightly increases lifespan of post-reproductive worms. In conclusion, the percentage of the oxidized form of CoQ increases with age indicating higher oxidative stress or rather a decreased anti-oxidative capacity of aged animals. © 2014 BioFactors, 2014.
    BioFactors 05/2014; 40(3). DOI:10.1002/biof.1160 · 4.59 Impact Factor
  • Source
    • "Because of its importance in cell homeostasis, CoQ levels have been documented in various tissues. Levels of CoQ often decline with the progression of certain diseases (particularly degenerative diseases) [12] [13] [14] [15] and upon aging in general [16] [17] [18] [19] [20]. "
    [Show abstract] [Hide abstract]
    ABSTRACT: Coenzyme Q plays an integral role in oxygen metabolism and management, and there is a positive correlation between low tissue coenzyme Q concentrations and the progression of many degenerative diseases. Retinal oxidative damage plays a role in the pathogenesis of many degenerative eye diseases; nevertheless, despite the retina's high rate of oxygen metabolism, there is little data relating to retinal coenzyme Q concentrations. In this study, we quantified coenzyme Q in the model bovine eye and determined whether it could function as a retinal lipid antioxidant. We found that the neural retina's ubiquinone concentration exceeded those of the vitreous humor, lens, choroid, and extraocular muscle, but it was lower than those measured in heart, kidney, liver, and brain tissues. Ubiquinol was found to be as effective as vitamin E as a retinal lipid antioxidant. The overall relatively low levels of ubiquinone found in the retina, coupled with the retina's need for lipid antioxidants and oxidative metabolism, suggests that retinal function might be sensitive to changes in ubiquinone concentrations.
    BioFactors 09/2011; 37(5):393-8. DOI:10.1002/biof.166 · 4.59 Impact Factor
Show more