Article

Synthesis and vesicle formation of a nido-carborane cluster lipid for boron neutron capture therapy.

Department of Chemistry, Faculty of Science, Gakushuin University, Tokyo 171-8588, Japan.
Chemical Communications (impact factor: 6.17). 10/2004; DOI:10.1039/b406141a pp.1910-1
Source: PubMed

ABSTRACT The nido-carborane lipid, which has a double-tailed moiety, was synthesized from heptadecanol in 5 steps. Analysis in a transmission electron microscope by negative staining with uranyl acetate showed that the lipid formed a stable vesicle in which calcein was encapsulated. The lipid was incorporated into distearoylphosphatidylcholine (DSPC) liposomes at a very high concentration.

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Keywords

distearoylphosphatidylcholine
 
double-tailed moiety
 
heptadecanol
 
negative staining
 
stable vesicle
 
transmission electron microscope
 
uranyl acetate