Acute Myeloid Leukemia With t(6;9)(p23;q34) Is Associated With Dysplasia and a High Frequency of flt3 Gene Mutations

Department of Hematopathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
American Journal of Clinical Pathology (Impact Factor: 3.01). 10/2004; 122(3):348-58. DOI: 10.1309/5DGB-59KQ-A527-PD47
Source: PubMed

ABSTRACT We report 12 cases of t(6;9)(p23;q34)-positive acute myeloid leukemia (AML), all classified using the criteria of the World Health Organization classification. There were 10 women and 2 men with a median age of 51 years (range, 20-76 years). Dysplasia was present in all cases (9 previously untreated), and basophilia was present in 6 (50%). Immunophenotypic studies showed that the blasts were positive for CD9, CD13, CD33, CD38, CD117, and HLA-DR in all cases assessed. CD34 was positive in 11 (92%) of 12, and terminal deoxynucleotidyl transferase was positive in 7 (64%) of 11 cases. The t(6;9) was the only cytogenetic abnormality detected in 7 cases (58%), and 5 cases had additional chromosomal abnormalities. Of 8 cases assessed, 7 (88%) had flt3 gene mutations. We conclude that t(6;9)-positive AML cases have distinctive morphologic features, an immunophenotype suggesting origin from an early hematopoietic progenitor cell, and a high frequency of flt3 gene mutations.

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    • "FLT3-ITD mutations have been reported in 20e30% of younger adult patients with AML, and FLT3/ TKD (D835) mutations in 7% [22]. These mutations have an adverse impact on prognosis and have been reported in 71e88 % of patients with the t(6;9) [1] [9]. FLT3 mutations were present in 54% of our patients, all of whom had FLT3 eITD. "
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