No link between low-grade periodontal disease and preterm birth: a pilot study in a healthy Caucasian population.

Faculty of Odontology, University of Iceland, Reykjavik.
Acta Odontologica Scandinavica (Impact Factor: 1.31). 07/2004; 62(3):177-9. DOI: 10.1080/00016350410001522
Source: PubMed
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    ABSTRACT: The present study was designed to find any association of cytokines in women with periodontal disease and development of preeclampsia in North Indian population. Five hundred four consecutively registered primigravida with a single live pregnancy were recruited at 14 to 18 weeks of gestation from antenatal clinic of Maulana Azad Medical College & associated Lok Nayak Hospital and Maulana Azad Institute of Dental Sciences, New Delhi. One periodontist performed oral health examination of all patients at inclusion into study. Blood samples were collected to measure the level of cytokines IL-4, IL-10, TNF-α and IFN-γ. The profile of blood levels of cytokines from women with periodontal disease was observed. The log serum levels of TNF-α & IL-4 at 16-18 weeks of gestation were significantly higher in women with periodontal disease (4.13±2.06;0.47±1.56pg/ml respectively) than in women with healthy gums (2.16±1.51;0.02±1.84pg/ml respectively)(p<0.001). Periodontal disease is associated with log serum TNF-α levels at cut-off≥14.43pg/ml at sensitivity 71.2% and specificity 62% (OR=4.04;95%CI=2.77-5.87). Woman with periodontal disease who later developed preeclampsia had lower levels of TNF-α(3.72±1.33pg/ml) than those with periodontal disease who did not develop preeclampsia (4.20±2.15pg/ml)(p≥0.05). Reduced TNF-α level secretion in the early second-trimester in women with periodontal disease appears to be associated with the development of preeclampsia. This article is protected by copyright. All rights reserved.
    Journal Of Clinical Periodontology 01/2014; DOI:10.1111/jcpe.12226 · 3.61 Impact Factor
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    ABSTRACT: Up frameshift (Upf) factors eliminate aberrant mRNAs containing a specific premature termination codon (PTC). Here, we show that Upf facilitate the ubiquitin-dependent degradation of products derived from mRNA containing specific PTCs in S.cerevisiae. The efficiency of recruitment of the Upf complex to a PTC product was correlated with the decay of the PTC product. Upf factors promoted the degradation of the human von Hippel Lindau (VHL) protein, which is an unfolded protein in yeast cells, in a manner that depends on the presence of a faux 3'UTR. Mass spectrometric analysis and Western blot analysis revealed that HSP70 was associated with the PTC product. These findings suggest that the Upf complex may be recruited to ribosomes depending in a faux 3' UTR dependent manner, and then associates with aberrant products to facilitate their degradation by the proteasome.
    Journal of Biological Chemistry 08/2013; 288(40). DOI:10.1074/jbc.M113.460691 · 4.60 Impact Factor
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    ABSTRACT: Abstract Objective. The aim of this study is to verify the existence of an association between maternal periodontal disease and pre-term delivery in an unselected population of post-partum Turkish women. Materials and methods. This case-control study was conducted on 100 women who gave birth in either a special or a government maternity hospital. The case group consisted of 50 mothers who had delivered an infant before 37 weeks' gestation and weighed under 2500 g. The control group included 50 mothers who had given birth to an infant with a birth weight of more than 2500 g and a gestational age of ≥37 weeks. Data of mothers and infants were collected using medical registers and questionnaires. Clinical periodontal examinations were carried out in six sites on every tooth in the mother's mouth. A participant who presented at least four teeth with one or more sites with a PPD ≥4 mm and CAL ≥3 mm at the same site was considered to have periodontal disease. Statistical methods included parametric and non-parametric tests and multiple logistic regression analysis. Results. There were no statistically significant differences between the cases and controls with regard to periodontal disease and pre-term delivery (OR = 1.48; 95% CI = 0.54-4.06). Conclusion. The findings indicated that maternal periodontitis was not a possible risk factor for pre-term delivery. Further studies with additional clinical trials are needed to explore the possible relationship between periodontal disease and pre-term birth.
    Acta Odontologica Scandinavica 05/2014; 72(8):1-8. DOI:10.3109/00016357.2014.919663 · 1.31 Impact Factor