Molecular structure of human geminin.

Bloomsbury Centre of Structural Biology, Birkbeck College, Malet Street, London, WC1E 7HX, UK.
Nature Structural & Molecular Biology (Impact Factor: 11.63). 11/2004; 11(10):1021-2. DOI: 10.1038/nsmb835
Source: PubMed

ABSTRACT The origin licensing repressor geminin is a unique bifunctional protein providing a molecular link between cellular proliferation, differentiation and genomic stability. Here we report the first molecular structure of human geminin, determined by EM and image processing at a resolution of 17.5 A. The geminin molecule is a tetramer formed by two dimers with monomers interacting via coiled-coil domains. The unusual structural organization of geminin provides molecular insight into its bifunctional nature.

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