Article

Placental yolk sac tumor with divergent endodermal differentiation.

Second Department of Pathology, Showa University School of Medicine, Tokyo, Japan.
International Journal of Gynecological Pathology (impact factor: 1.45). 11/2004; 23(4):398-402. pp.398-402
Source: PubMed

ABSTRACT We report an intraplacental germ cell tumor that was an incidental finding in the placenta of a 34-year-old woman. On pathologic examination, the 4.0-cm tumor was well circumscribed with a thin fibrous capsule. It exhibited three major histologic patterns within a mesenchyme-like myxoid background: a primitive endodermal component, a well-differentiated enteric glandular endodermal component, and a component of fetal hepatic tissue. The primitive endodermal component, the hepatic component, and many parts of the enteric endodermal glandular component were immunoreactive for alpha-fetoprotein. We considered the lesion to be a unique example of a placental yolk sac tumor and only the second reported case of a placental yolk sac tumor.

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Keywords

34-year-old woman
 
enteric endodermal glandular component
 
fetal hepatic tissue
 
incidental
 
intraplacental germ cell tumor
 
mesenchyme-like myxoid background
 
parts
 
placental yolk sac tumor
 
primitive endodermal component
 
unique example
 
well-differentiated enteric glandular endodermal component
 

Taka-Aki Matsuyama