Hilar cholangiocarcinoma: staging with intrabiliary MRI.
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Article: MRI-guided gene therapy[Show abstract] [Hide abstract]
ABSTRACT: MRI has the ability to generate high-contrast and high-resolution images, to obtain multiple diagnostic evaluations of organ function and morphology, and to provide multiple image planes with no risk of ionizing radiation. Recent efforts have focused on using MR technology to monitor gene delivery, to enhance gene transfection/transduction, and to track gene expression. This review summarizes the current status of MRI-guided gene therapy.FEBS Letters 06/2006; 580(12):2958-61. DOI:10.1016/j.febslet.2006.04.027 · 3.34 Impact Factor
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ABSTRACT: Miniature flexible RF coils for magnetic resonance imaging have been constructed using electroplated conductors and substrates formed in SU-8 epoxy photoresist. The coils are batch fabricated on glass wafers, removed by thermal shock and integrated into a catheter probe designed for endoscopic insertion into the bile duct. 1 H MRI with at least 1 mm resolution is demonstrated in vitro using microfabricated phantoms and liver tissue at 1.5 T.
Article: Intrabiliary MR imaging.[Show abstract] [Hide abstract]
ABSTRACT: The goal of this research is to illustrate the potential role of interventional MR imaging ina clinical setting. As shown by this study, IBMR is feasible, is well tolerated, and positively affects patient management. IBMR allowed for significantly decreased field of view and high in-plane resolution and provided contrast between the biliary lumen and adjacent structures with high diagnostic accuracy. This technique enabled clinicians not only to improve imaging of the biliary tree but also to make a more accurate diagnosis. Based on this pilot work, there are several potential avenues of further expansion for IBMR. For example, enhanced imaging of the biliary tree may allow for monitoring of new biliary treatment regimens such as photodynamic therapy or molecular targeting. In addition, this technique may also foster development of innovative new percutaneous procedures that may eventually treat some biliary disorders under MR imaging guidance.Magnetic Resonance Imaging Clinics of North America 09/2005; 13(3):481-9. DOI:10.1016/j.mric.2005.04.011 · 0.80 Impact Factor