Hilar cholangiocarcinoma: staging with intrabiliary MRI.
The Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutes, Blalock 544, 600 N Wolfe St., Baltimore, MD 21287, USA.American Journal of Roentgenology (Impact Factor: 2.74). 11/2004; 183(4):1071-4. DOI: 10.2214/ajr.183.4.1831071
Article: Intrabiliary MR imaging.[Show abstract] [Hide abstract]
ABSTRACT: The goal of this research is to illustrate the potential role of interventional MR imaging ina clinical setting. As shown by this study, IBMR is feasible, is well tolerated, and positively affects patient management. IBMR allowed for significantly decreased field of view and high in-plane resolution and provided contrast between the biliary lumen and adjacent structures with high diagnostic accuracy. This technique enabled clinicians not only to improve imaging of the biliary tree but also to make a more accurate diagnosis. Based on this pilot work, there are several potential avenues of further expansion for IBMR. For example, enhanced imaging of the biliary tree may allow for monitoring of new biliary treatment regimens such as photodynamic therapy or molecular targeting. In addition, this technique may also foster development of innovative new percutaneous procedures that may eventually treat some biliary disorders under MR imaging guidance.Magnetic Resonance Imaging Clinics of North America 09/2005; 13(3):481-9. · 0.80 Impact Factor
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ABSTRACT: To investigate the feasibility of using magnetic resonance (MR) imaging to monitor intrabiliary delivery of motexafin gadolinium (MGd) into pig common bile duct (CBD) walls. Animal studies were approved by the Institutional Animal Care and Use Committee. Initially, human cholangiocarcinoma cells were treated with various concentrations of MGd, a compound serving as a T1-weighted MR imaging contrast agent, chemotherapy drug, and cell marker. These cells were then examined by means of confocal microscopy to confirm the intracellular uptake of MGd. In addition, an MGd/trypan blue mixture was locally infused into CBD walls of six cadaveric pigs using a microporous balloon catheter. CBDs of six pigs were infused with saline to serve as controls. Ex vivo T1-weighted MR imaging of these CBDs was performed. For in vivo technical validation, the microporous balloon catheter was placed in the CBD by means of a transcholecytic access to deliver MGd/trypan blue into CBD walls of six living pigs. T1-weighted images were obtained with both a surface coil and an intrabiliary MR imaging guidewire, and contrast-to-noise ratios of CBD walls before and after MGd/trypan blue infusions were compared in the two groups by means of paired t test, with subsequent histologic analysis to confirm the penetration and distribution of the MGd/trypan blue agent into CBD walls. In vitro experiments confirmed uptake of MGd by human cholangiocarcinoma cells. The ex vivo experiments demonstrated the penetration of MGd/trypan blue into the CBD walls. The in vivo experiment confirmed the uptake of MGd/trypan blue, showing an increased contrast-to-noise ratio for the CBD after administration of the mixture, compared with images obtained prior to MGd/trypan blue administration (11.6 ± 4.2 [standard deviation] vs 5.7 ± 2.8; P = .04). Histologic results depicted the blue dye stains and red fluorescence of MGd in CBD walls, confirming the imaging findings. It is feasible to use MR imaging to monitor the penetration of locally delivered MGd into pig CBD walls.Radiology 03/2012; 262(3):846-52. · 6.21 Impact Factor
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ABSTRACT: Miniature flexible RF coils for magnetic resonance imaging have been constructed using electroplated conductors and substrates formed in SU-8 epoxy photoresist. The coils are batch fabricated on glass wafers, removed by thermal shock and integrated into a catheter probe designed for endoscopic insertion into the bile duct. 1 H MRI with at least 1 mm resolution is demonstrated in vitro using microfabricated phantoms and liver tissue at 1.5 T.
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