Cholesterolosis Incidence correlation with serum cholesterol level and the role of laparoscopic cholecystectomy

Department of Surgery (37), Faculty of Medicine and King Khalid University Hospital, PO Box 7805, Riyadh 11472, Kingdom of Saudi Arabia.
Saudi medical journal (Impact Factor: 0.59). 09/2004; 25(9):1226-8.
Source: PubMed


To report the incidence of cholesterolosis in the surgically removed gallbladders, its association with serum cholesterol level and to review the role of laparoscopic cholecystectomy in the treatment.
This retrospective study included all patients who had consecutive cholecystectomies for various gallbladder disorders, performed by 2 consultants during a 5-year period from January 1997 through to December 2002, in the College of Medicine and King Khalid University Hospital, King Saud University, Riyadh, Kingdom of Saudi Arabia. The clinical records of those found to have cholesterolosis on histopathological examination were reviewed, and the data were analyzed for their age, sex, fasting serum cholesterol level and the final outcome of cholecystectomy.
The study group was comprised of 549 patients and out of which, 74 (13.4%) had cholesterolosis of the gallbladder. There were 59 (79.9%) female and 15 (20.1%) male patients. Age ranged from 18-64-years with a mean of 35.7-years. Sixty-three (85.1%) cases were reported to have abnormally high fasting serum cholesterol levels (>=5.5 mmol/L), whereas 11 (14.9%) had normal serum cholesterol level. Cholesterolosis with coexistent gallstones was documented in 47 (63.3%) patients while 27 (36.5%) subjects showed acalculous cholesterolosis. Laparoscopic cholecystectomy was performed in 71 (95.9%) individuals, whereas 3 patients ended up with open cholecystectomy (conversion rate of 4.2%). There were no postoperative complications.
Cholesterolosis of the gallbladder is a distinct pathologic entity and carries a positive correlation with high serum cholesterol level. Laparoscopic cholecystectomy is effective, safe and a feasible treatment modality for cholesterolosis.

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Available from: Khalid Rida Murshid, Oct 07, 2015
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    • "Most GBP are cholesterol polyps. Although the pathogenesis of GBP remains poorly understood, several investigators have hypothesized that direct deposition of bile or blood cholesterol may contribute to the formation of cholesterol polyps (26). In support of this mechanism, a similar association has been suggested between GBP and lipid profile abnormalities (27, 28). "
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    ABSTRACT: Only a few studies have evaluated the population-adjusted prevalence of gallbladder polyps (GBP). This study aimed to evaluate the changes in GBP prevalence and risk factors at a single health screening center in Korea from 2002 to 2012. Of 48,591 adults who underwent health screening between 2002 and 2012, 14,250 age- and gender-matched subjects were randomly selected to evaluate prevalence. Risk factors were analyzed between the GBP-positive and GBP-negative groups during 2002-2004 (Period A) and 2010-2012 (Period B). The annual prevalence of GBP over the 11-yr period was 5.4%. Annual prevalence increased from 3.8% in Period A to 7.1% in Period B. Male gender and obesity were independent risk factors for GBP in both periods. Hepatitis B virus surface antigen (HBsAg) positivity was a risk factor for GBP in Period A but not in Period B. The risk factors for GBP changed from HBsAg positivity to lipid profile abnormalities. Other variables including age, hypertension, diabetes, impaired fasting glucose, chronic hepatitis C virus infection, and liver function tests did not correlate with GBP. In conclusion, GBP prevalence is increasing and risk factors for GBP have changed in Korea. More attention should be paid to this issue in the future.
    Journal of Korean Medical Science 09/2014; 29(9):1247-52. DOI:10.3346/jkms.2014.29.9.1247 · 1.27 Impact Factor
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    • "Khairy et al.14 reported a positive association between high serum cholesterol levels and cholesterol gallstone development. Similarly, Halldestam et al.1 and Andreotti et al.15 argued that high serum cholesterol levels are positively correlated with gallstone disease. "
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    ABSTRACT: Objective: Gallbladder stones are common in the Western world, and 70% to 80% of gallstones are cholesterol stones. This study investigates the effects of serum cholesterol, LDL, and HDL levels on gallstone cholesterol concentration. Methodology: The gallstones of 75 patients with cholelithiasis were examined using spectrophotometry. Results: High serum cholesterol and LDL levels were associated with high cholesterol stone rates (86.7% vs. 40.0%, P < 0.001; 75.0% vs. 48.9%, P < 0.05, respectively). Similarly, high serum cholesterol and LDL levels were correlated with high gallbladder stone cholesterol concentrations (63.6% vs. 44.4%, P < 0.001; 62.3% vs. 46.0%, P < 0.001, respectively). In contrast, low serum HDL levels do not seem to affect the occurrence of gallbladder cholesterol stones (60.0% vs. 58.3%, respectively, P > 0.05) or gallbladder stone cholesterol concentrations (50.8% vs. 52.4%, respectively, P > 0.05). Conclusion: The relationship between cholesterol, LDL, and HDL levels and cholesterol gallstone formation is multifactorial and complex and is also dependent on other individual properties.
    Pakistan Journal of Medical Sciences Online 09/2013; 29(1):187-90. DOI:10.12669/pjms.291.2798 · 0.23 Impact Factor
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    ABSTRACT: The purpose of this study was to describe the pathologic findings of the gallbladder in patients who underwent simultaneous cholecystectomy and hepatectomy for hepatocellular carcinoma in Taiwan. This was a hospital-based retrospective study. The authors analyzed the medical records of all subjects with hepatocellular carcinoma who were initially treated by hepatic resection and cholecystectomy at 1 medical center in Taiwan from 1995 to 2008. Totally, 549 subjects were enrolled in this study. There were 428 men (78.0%) and 121 women (22.0%). The mean age was 55.6 ± 13.2 years (range, 15-88 years). Among the 549 subjects with hepatocellular carcinoma, only 1 patient (0.2%) had gallbladder metastasis. The prevalence of gallstones was 9.3%; the prevalence of cholesterolosis of the gallbladder was 6.6%; and the prevalence of cholesterol polyp of the gallbladder was 0.9%. The prevalence of metastasis from hepatocellular carcinoma to the gallbladder is low. Other lesions inside the gallbladder among patients with hepatocellular carcinoma are benign and they do not always require cholecystectomy.
    The American Journal of the Medical Sciences 02/2011; 341(4):305-7. DOI:10.1097/MAJ.0b013e3182061674 · 1.39 Impact Factor
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