Multimicronutrient interventions but not vitamin a or iron interventions alone improve child growth: results of 3 meta-analyses.
ABSTRACT Meta-analyses of randomized controlled intervention trials were conducted to assess the effects of vitamin A, iron, and multimicronutrient interventions on the growth of children < 18 y old. A PubMed database search and other methods identified 14 vitamin A, 21 iron, and 5 multimicronutrient intervention studies that met the design criteria. Weighted mean effect sizes and CI were calculated using a random effects model for changes in height and weight. Tests for homogeneity and stratified analyses by predefined characteristics were conducted. Vitamin A interventions had no significant effect on growth; effect sizes were 0.08 (95% CI: -0.20, 0.36) for height and -0.01 (95% CI: -0.24, 0.22) for weight. Iron interventions also had no significant effect on child growth. Overall effect sizes were 0.09 (95% CI: -0.07, 0.24) for height and 0.13 (95% CI: -0.05, 0.30) for weight. The results were similar across categories of age, duration of intervention, mode and dosage of intervention, and baseline anthropometric status. Iron interventions did result in a significant increase in hemoglobin (Hb) concentrations with an effect size of 1.49 (95% CI: 0.46, 2.51). Multimicronutrient interventions had a positive effect on child growth; the effect sizes were 0.28 (95% CI: 0.16, 0.41) for height and 0.28 (95% CI: -0.07, 0.63) for weight. Interventions limited to only vitamin A or iron did not improve child growth. Multimicronutrient interventions, on the other hand, improved linear and possibly ponderal growth in children.
- SourceAvailable from: Venkata Raghava Mohan[Show abstract] [Hide abstract]
ABSTRACT: The overall goal of The Etiology, Risk Factors and Interactions of Enteric Infections and Malnutrition and the Consequences for Child Health and Development (MAL-ED) cohort study is to evaluate the roles of repeated enteric infection and poor dietary intakes on the development of malnutrition, poor cognitive development, and diminished immune response. The use of 8 distinct sites for data collection from Latin America, sub-Saharan Africa, and South Asia allow for an examination of these relationships across different environmental contexts. Key to testing study hypotheses is the collection of appropriate data to characterize the dietary intakes and nutritional status of study children from birth through 24 months of age. The focus of the current article is on the collection of data to describe the nature and adequacy of infant feeding, energy and nutrient intakes, and the chosen indicators to capture micronutrient status in children over timeClinical Infectious Diseases. 11/2014; 59(suppl 4):S248-S254.
Article: Anemia and growth[Show abstract] [Hide abstract]
ABSTRACT: Chronic anemia has a negative effect on linear growth during all stages of growth (infancy, childhood and adolescence). In addition, infants with chronic IDA have delayed cognitive, motor, and affective development that may be long-lasting. The mechanisms of defective growth in IDA includes defective IGF-I secretion. Correction of anemia is associated with an improvement of catch-up growth and a signifi cant increase in IGF-I secretion.Indian J Endocrinology and Metabolism. 11/2014; 18(1).
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ABSTRACT: The island-wide comprehensive supplementary feeding scheme known as 'Thriposha' programme has been in existence in the country for over three decades. Its effectiveness on growth, however, has not yet been evaluated. We examined the effects of Thriposha dietary supplementation on anthropometric parameters (weight & height) among preschool children in Galle. Preschool children (aged 3-5 years) from two well-baby clinics grouped into interventional (n=137) arm and control (n = 130) arm, were fed with ordinary Thriposha (50 g/day) and Thriposha made without mineral and vitamin premix, respectively for a period of nine months. Height and weight were recorded using a portable stadiometer and a beam balance, respectively at baseline and after 5 months and 9 months of intervention. At the end of 9 months, weight gain in the intervention group was +1.35 (0.6) Kg, whereas it was +1.22 (0.5) Kg (p = 0.08 for the between group difference) in the control. The height gain was +4.76 (1.3) cm in intervention group, whereas control group had +3.14 (2.1) cm of height gain (p < 0.001 for the between group difference). There was no treatment effect on weight in children aged <48 months, whereas those who were gain > 48 months in the Intervention group had significant (p = 0.05) weight over the control group children. We confirm that regular consumption of conventional Thriposha for 9 months have a positive effect on height and weight gain among preschool children.Galle Medical Journal. 10/2011; 16(2).