Waters, J., Schaefer, A. & Sakmann, B. Backpropagating action potentials in neurones: measurement, mechanisms and potential functions. Prog. Biophys. Mol. Biol. 87, 145-170

Abteilung Zellphysiologie, Max-Planck-Institut für medizinische Forschung, Jahnstrasse 29, Heidelberg D-69120, Germany.
Progress in Biophysics and Molecular Biology (Impact Factor: 2.27). 02/2005; 87(1):145-70. DOI: 10.1016/j.pbiomolbio.2004.06.009
Source: PubMed


Here we review some properties and functions of backpropagating action potentials in the dendrites of mammalian CNS neurones. We focus on three main aspects: firstly the current techniques available for measuring backpropagating action potentials, secondly the morphological parameters and voltage gated ion channels that determine action potential backpropagation and thirdly the potential functions of backpropagating action potentials in real neuronal networks.

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Available from: Andreas T Schaefer, Feb 06, 2015
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    • "he dendritic arbor ( Stuart and Sakmann , 1994 ) . A bAP serves as a retrograde signal , conveying the level of neuronal output activity to the dendrites . Indeed , bAPs attenuate in amplitude along the somato - dendritic axis as they propagate from proximal to distal locations ( Stuart and Sakmann , 1994 ; for reviews see Stuart et al . , 1997b ; Waters et al . , 2005 ) . Preliminary computational modeling studies have indicated that the morphology of the TTL5 dendritic arbor influences the back - propagation of APs ( Vetter et al . , 2001 ) . Another discovery , also in Bert Sakmann ' s laboratory , provided the first evidence that EPSPs caused a transient increase in [ Ca 2+ ] i mediated by the ope"
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    • "From a modeling standpoint, one can also consider spiking neural circuits in which, in addition to feedforward input, every neuron may receive lateral inputs from neurons in the same layer. Furthermore, back-propagating action potentials (Waters et al., 2005), or feedback, may affect computations performed within the dendritic tree. Until now, CIMs for circuits with lateral connectivity and feedback have only been considered in the context of scalar or vector-valued signals of one variable, e.g., functions of time u 1 (t), t ∈ R. "
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    • "Neurons communicate with each other through the generation of action potentials, which are initiated in the axon initial segment and propagate to the axon terminal (orthodromic propagation), and back into the soma and dendrites (antidromic propagation or backpropagation; Spruston et al., 1995; Stuart et al., 1997b; Bernard and Johnston, 2003). The discovery of a multitude of voltage- and ligand-gated ion channels in the dendrites extended their original concept as passive tubes to include active complex computational properties (Stuart and Sakmann, 1995; Häusser and Mel, 2003; Waters et al., 2005; Froemke et al., 2010), establishing their role as integrative cellular elements. Previous reports showed that the propagation of the antidromic spike along the dendritic arbors depends on the type of neuron, and is highly dependent on Na+ conductance along the dendritic tree (Colbert et al., 1997; Stuart et al., 1997a) as well as dendritic morphology (Vetter et al., 2001). "
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