Article

Early treatment of a migraine attack while pain is still mild increases the efficacy of sumatriptan.

Medical Department, GlaxoSmithKline, Muenchen, Germany.
Cephalalgia (impact factor: 3.43). 12/2004; 24(11):925-33. DOI:10.1111/j.1468-2982.2004.00802.x pp.925-33
Source: PubMed

ABSTRACT To investigate the hypothesis that early treatment of a migraine attack with sumatriptan, while pain is still mild, results in higher pain free rates in comparison to delayed treatment, when pain is at least moderate, we performed a prospective, controlled and open label study. Migraineurs with or without aura who fulfilled the diagnostic criteria recommended by the International Headache Society were enrolled in the study and randomly assigned to either 'early' or 'late' treatment with sumatriptan 100 mg tablets. In the early treatment group significantly more patients were pain free at all times measured during two hours after dosing than in the late treatment group. Furthermore, patients in the early treatment group became pain free significantly sooner after dosing than patients who delayed treatment. It is concluded that migraineurs, who are able to differentiate between a migraine attack and other forms of headache, benefit from early intervention with sumatriptan 100 mg tablets.

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Keywords

'late' treatment
 
able
 
aura
 
diagnostic criteria
 
higher pain free rates
 
International Headache Society
 
migraine attack
 
migraineurs
 
pain free
 
patients
 
prospective
 
sumatriptan
 
sumatriptan 100 mg tablets
 
times
 
treatment group
 

J Scholpp