Article

Burning mouth syndrome: The efficacy of lipoic acid on subgroups

Stomatology Clinic, II University of Medicine and Surgery, Naples, Italy.
Journal of the European Academy of Dermatology and Venereology (Impact Factor: 3.11). 12/2004; 18(6):676-8. DOI: 10.1111/j.1468-3083.2004.01049.x
Source: PubMed

ABSTRACT We have examined the effect of alpha-lipoic acid (ALA, tioctic acid; Tiobec), a free radical scavenger, on the discomfort of burning mouth syndrome (BMS) in patients who had used tranquillizers previously, compared with those who had not.
In this study we gave lipoic acid for 2 months to two groups of 20 BMS patients, one of which had previously been treated with tranquillizers.
The results showed greater effectiveness of lipoic acid in BMS patients who had not previously used tranquillizers.
The patients with BMS who had previously been treated with tranquillizers responded poorly to therapy with lipoic acid compared with those who had not received previous psychotropic therapy.

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    • "Deux études du même groupe ont montré un effet de l'acide alpha-lipoïque (utilisé pour le traitement des douleurs neuropathiques diabétiques) versus placebo utilisé seul, mais avec des biais méthodologiques [165] [166] ; ces résultats n'ont pas été confirmés dans deux études ultérieures [167] [168], ce qui ne plaide pas en faveur de son utilisation seule. En revanche, son association à la gabapentine (300 mg) [169] [170] a prouvé une certaine efficacité. "
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