The Lambeth Early Onset (LEO) Team: Randomised controlled trial of the effectiveness of specialised care for early psychosis

The University of Manchester, Manchester, England, United Kingdom
BMJ (online) (Impact Factor: 17.45). 12/2004; 329(7474):1067. DOI: 10.1136/bmj.38246.594873.7C
Source: PubMed


To evaluate the effectiveness of a service for early psychosis.
Randomised controlled clinical trial.
Community mental health teams in one London borough.
144 people aged 16-40 years presenting to mental health services for the first or second time with non-organic, non-affective psychosis.
Assertive outreach with evidence based biopsychosocial interventions (specialised care group) and standard care (control group) delivered by community mental health teams.
Rates of relapse and readmission to hospital.
Compared with patients in the standard care group, those in the specialised care group were less likely to relapse (odds ratio 0.46, 95% confidence interval 0.22 to 0.97), were readmitted fewer times (beta 0.39, 0.10 to 0.68), and were less likely to drop out of the study (odds ratio 0.35, 0.15 to 0.81). When rates were adjusted for sex, previous psychotic episode, and ethnicity, the difference in relapse was no longer significant (odds ratio 0.55, 0.24 to 1.26); only total number of readmissions (beta 0.36, 0.04 to 0.66) and dropout rates (beta 0.28, 0.12 to 0.73) remained significant.
Limited evidence shows that a team delivering specialised care for patients with early psychosis is superior to standard care for maintaining contact with professionals and for reducing readmissions to hospital. No firm conclusions can, however, be drawn owing to the modest sample size.

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