Does referral bias impact findings in high-risk offspring for anxiety disorders? A controlled study of high-risk children of non-referred parents with panic disorder/agoraphobia and major depression

Pediatric Psychopharmacology Program and the Department of Psychiatry, Massachusetts General Hospital, Warren 705, 15 Parkman St., Boston, MA 02114, USA.
Journal of Affective Disorders (Impact Factor: 3.38). 11/2004; 82(2):209-16. DOI: 10.1016/j.jad.2003.12.015
Source: PubMed


Previous findings in referred samples documented significant diagnostic specificity in patterns of transmission between parents with panic disorder (PD) and parents with major depression (MD) and their offspring. This study evaluated whether these patterns of transmission between parents and high-risk offspring are moderated by referral bias.
Parental PD/agoraphobia (AG) and parental MD were used to predict rates of offspring psychiatric disorders and functional outcomes using data from an opportunistic sample of parents (n = 991) and offspring (n = 734) ascertained from case-control family genetic studies of youth with and without attention-deficit hyperactivity disorder. Subjects were comprehensively assessed with structured diagnostic interview methodology to evaluate psychiatric disorders in parents and offspring.
Parental PD/AG increased the risk for anxiety disorders in offspring, independently of parental MD while parental MD increased the risk for mood and disruptive behavior disorders in offspring, independently of parental PD/AG. Parental psychopathology was also associated with functional impairment in offspring.
The use of a sample ascertained by ADHD and control probands, and parent psychiatric diagnostic reports for children under 12.
These results extend to non-referred samples previous findings from referred samples documenting diagnostic specificity in the familial transmission of PD/AG and MD from parents to offspring, suggesting that these patterns of transmission are not due to referral bias. These results could inform and enhance community programs aimed at screening for and treating pediatric psychopathology.

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    • "Bei Kindern schizophrener Eltern wird auch auf ein erhöhtes Risiko hingewiesen, unspezifische Aufmerksamkeitsstörungen oder A ¨ ngstlichkeit zu generieren (Remschmidt & Mattejat, 1994). Kinder von substanzmissbrauchenden Vätern weisen ein erhöhtes psychiatrisches Erkrankungsrisiko für affektive und Angststörungen auf (Kelley & Fals-Stewart, 2004), auch für Kinder von Eltern mit Angst-und Zwangsstörungen ist das unspezifische Risiko erhöht (Biederman et al., 2004). Kinder von Eltern mit Persönlichkeitsstörungen sind im Vergleich zu anderen elterlichen Diagnosegruppen am meisten beeinträchtigt (Wiegand-Grefe et al., 2011a). "

    Kindheit und Entwicklung 01/2013; 22(1):31-40. · 3.50 Impact Factor
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    • "There is some evidence for a familial aggregation of panic disorder (PD) from various types of clinical and non-clinical family studies. Studies show higher rates of PD in all first-degree relatives [Brown, 1994; Burrows et al., 1989; Crowe et al., 1983; Fyer et al., 1995, 1996; Gruppo Italiano Disturbi d'Ansia, 1989; Hopper et al., 1987; Maier et al., 1993; Mannuzza et al., 1994; Mendlewicz et al., 1993; Noyes et al., 1986; Weissman et al., 1993] and particularly in offspring [Biederman et al., 2004; Hopper et al., 1990; Weissman et al., 1984] of PD patients compared to relatives of controls. Hayward et al. [2004] suggest that parental history of PD/agoraphobia (AG) may play the main role in the development of panic attacks (PA) in adolescents. "
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    ABSTRACT: To examine the familial liability of panic disorder (PD) and agoraphobia (AG) in a community sample, namely the effect of parental PD and AG on the offspring's risk to develop either or both conditions in adolescence or adulthood. A representative community sample of N=3,021 adolescents and young adults aged 14-24 years at baseline was followed up over a period of 10 years in up to four waves. Family information was assessed by either direct interviews with at least one parent or by using subjects' family history information at either wave (N=3,014). Diagnoses and selected symptoms were assessed in both, parents and subjects, by using a standardized diagnostic interview (DSM-IV M-CIDI) with its respective family history module. (1) Parental panic attacks (PA), PD, and AG were all shown to be associated with an increased risk of offspring to also develop PA, PD, and AG. (2) Associations of parental PD were present irrespective of parental AG, whereas parental AG without PD was not associated with an increased offspring risk. (3) Outcome risk was particularly elevated in offspring of parents with PD+AG. (4) Parental PD or AG was not associated with an earlier age of onset of any syndrome in the offspring. We confirmed and expanded previous results from clinical samples that comorbid PD and AG aggregate in families. AG without PD is not familial, but it might enhance the familial transmission of PD.
    Depression and Anxiety 05/2008; 25(5):422-34. DOI:10.1002/da.20425 · 4.41 Impact Factor
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    ABSTRACT: Previous findings in referred adult samples document major depression as having important moderating effects on the patterns of comorbidity for panic disorder and major depression. This study evaluated whether these patterns of comorbidity are moderated by referral bias. Panic disorder (PD) and major depression (MD) were used to predict the risk for comorbid psychiatric disorders and functional outcomes using data from a large sample of adults who had not been ascertained on the basis of clinical referral (N=1,031). Participants were comprehensively assessed with structured diagnostic interview methodology to evaluate childhood and adult comorbid psychiatric disorders. PD increased the risk for anxiety disorders, independently of MD. MD increased the risk for mania, antisocial personality disorder, psychoactive substance use disorder, disruptive behavior disorders, overanxious disorder, social phobia, and generalized anxiety disorder, independently of PD. These results extend to nonreferred samples' previously reported findings documenting that MD has important moderating effects on patterns of comorbidity for PD and indicate that patterns of comorbidity for PD are not due to referral bias.
    Depression and Anxiety 01/2005; 21(2):55-60. DOI:10.1002/da.20055 · 4.41 Impact Factor
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