Article

Impact of fermented brown rice with Aspergillus oryzae (FEBRA) intake and concentrations of polybrominated diphenylethers (PBDEs) in blood of humans from Japan.

Shimadzu Techno-Research Inc., #1, Nishinokyo-Shimoaicho, Nakagyo-ku, Kyoto 604-8436, Japan.
Chemosphere (impact factor: 3.21). 12/2004; 57(8):795-811. DOI:10.1016/j.chemosphere.2004.07.016 pp.795-811
Source: PubMed

ABSTRACT The isotope dilution technique was applied for the analysis of new polybrominated diphenylethers (PBDEs) calibration standard (both labeled and non-labeled) using high-resolution gas chromatography-high-resolution mass spectrometry (HRGC-HRMS). The relative response factor (RRF) and relative standard deviation (RSD) for new calibration standard in Finnigan Thermo Electron (MAT-95XL) and Micromass (Autospec Ultima) were more or less identical with mean RRF (0.9882), RSD (0.0865) and CV% of (8.75). The results also revealed for DeBDE-209 quantification; labeled DeBDE-209 is essential. Furthermore, we recommend on column injection technique with a thin film instead of splitless injection in order to reduce the thermal degradation of DeBDE-209 and formation of octabromodibenzofurans (OBDF). Besides, analysis of human blood (n = 156) of FEBRA-intake and non-FEBRA-intake individuals elucidated frequent detection of eighteen PBDE congeners. The average PBDE concentrations in non-FEBRA intake and FEBRA-intake humans were 6000-11,000 (mean: 8400) and 5400-15,000 (mean: 9900) respectively on pg/g fat basis. Although FEBRA-intake individuals showed slightly greater PBDEs, computer-normalized concentrations of TeBDE-47 corroborate FEBRA-intake individual from four family showed reduced concentrations. The contamination profiles of PBDEs varied in between family, gender as well as geography. International comparison with predominant PBDE congener (TeBDE-47) prevailed lower levels in Japan when compared to Korea, Germany and USA nevertheless, congener specific profiles were different which is in accordance with different technical PBDE usage in between countries.

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    Article: Higher accumulation of polybrominated diphenyl ethers in infants than in adults.
    Leisa-Maree L Toms, Fiona Harden, Olaf Paepke, Peter Hobson, John Jake Ryan, Jochen F Mueller
    [show abstract] [hide abstract]
    ABSTRACT: Pooled serum samples collected from 8132 residents in 2002/ 03 and 2004/05 were analyzed to assess human polybrominated diphenyl ether (PBDE) concentrations from specified strata of the Australian population. The strata were defined by age (0-4 years, 5-15 years, < 16 years, 16-30 years, 31-45 years, 46-60 years, and > 60 years); region; and gender. For both time periods, infants and older children had substantially higher PBDE concentrations than adults. For samples collected in 2004/ 05, the mean +/- standard deviation sigmaPBDE (sum of the homologue groups for the mono-, di-, tri-, tetra-, penta-, hexa-, hepta-, octa-, nona-, and deca-BDEs) concentrations for 0-4 and 5-15 years were 73 +/- 7 and 29 +/- 7 ng g(-1) lipid, respectively, while for all adults > 16 years, the mean concentration was lower at 18 +/- 5 ng g(-1) lipid. A similar trend was observed for the samples collected in 2002/03, with the mean sigmaPBDE concentration for children < 16 years being 28 +/- 8 ng g(-1) lipid and for the adults >16 years, 15 +/- 5 ng g(-1) lipid. No regional or gender specific differences were observed. Measured data were compared with a model that we developed to incorporate the primary known exposure pathways (food, air, dust, breast milk) and clearance (half-life) data. The model was used to predict PBDE concentration trends and indicated that the elevated concentrations in infants were primarily due to maternal transfer and breast milk consumption with inhalation and ingestion of dust making a comparatively lower contribution.
    Environmental Science and Technology 10/2008; 42(19):7510-5. · 5.23 Impact Factor
Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. The impact factor represents a rough estimation of the journal's impact factor and does not reflect the actual current impact factor. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.

Keywords

average PBDE concentrations
 
column injection technique
 
computer-normalized concentrations
 
congener specific profiles
 
different technical PBDE usage
 
FEBRA-intake humans
 
FEBRA-intake individual
 
Finnigan Thermo Electron
 
greater PBDEs
 
human blood
 
isotope dilution technique
 
new calibration standard
 
new polybrominated diphenylethers
 
non-FEBRA-intake individuals elucidated frequent detection
 
PBDE congeners
 
pg/g fat basis
 
predominant PBDE congener
 
relative standard deviation
 
splitless injection
 
thin film