Alcohol-Associated Hypertension When One Drinks Makes a Difference

Hypertension (Impact Factor: 6.48). 01/2005; 44(6):805-6. DOI: 10.1161/01.HYP.0000146538.26193.60
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Available from: Arthur Klatsky, Apr 11, 2014
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    • "Metabolic syndrome is defined as the occurrence of 3 of any of the 5 following factors: obesity, elevated triglyceride (TG), low HDL-C, elevated blood pressure (BP), and elevated fasting glucose (FG) [3]. Lifestyle factors such as alcohol consumption, cigarette smoking, and physical activity have been reported to affect an individual's metabolic profile [4, 5]. A large population based study in the United States reported that mild to moderate alcohol consumption of alcohol was associated with a favorable influence on lipids, waist circumference, and fasting insulin in comparison to nondrinkers [4]. "
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    ABSTRACT: Background. Although there is a reported association between lifestyle factors and metabolic syndrome, very few studies have used national level data restricted to the African Americans (AAs) in the United States (US). Methods. A cross-sectional evaluation was conducted using the National Health and Nutrition Examination Survey from 1999 to 2006 including men and nonpregnant women of 20 years or older. Multiple logistic regression models were constructed to evaluate the association between lifestyle factors and metabolic syndrome. Results. AA women had a higher prevalence of metabolic syndrome (39.43%) than AA men (26.77%). After adjusting for sociodemographic factors, no significant association was found between metabolic syndrome and lifestyle factors including alcohol drinking, cigarette smoking, and physical activity. Age and marital status were significant predictors for metabolic syndrome. With increase in age, both AA men and AA women were more likely to have metabolic syndrome (AA men: OR(adj) = 1.05, 95% CI 1.04-1.06, AA women: OR(adj) = 1.06, 95% CI 1.04-1.07). Single AA women were less likely to have metabolic syndrome than married women (OR(adj) = 0.66, 95% CI 0.43-0.99). Conclusion. Lifestyle factors had no significant association with metabolic syndrome but age and marital status were strong predictors for metabolic syndrome in AAs in the US.
    Journal of nutrition and metabolism 01/2013; 2013:516475. DOI:10.1155/2013/516475
    • "Regarding the impact on the cardiovascular system, comorbidity as measured by the CIRS-SA includes conditions such as hypercholesterolemia and hypertension that are highly prevalent in alcoholic patients. In fact, it has been hypothesized that 5 to 30% of hypertension in the general population is attributable to alcohol abuse, and that alcohol consumption itself increases blood pressure in a dose– response relationship (Klatsky, 2004). "
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    ABSTRACT: The association between alcohol use disorders and increased risk of mortality is well known; however, there have been few systematic evaluations of alcohol-related organ damage and its impact on survival in younger alcoholics. Therefore, we assessed medical comorbidity with a clinical index to identify subgroups of alcoholic patients at high risk of premature death. Hospital-based cohort of alcohol-dependent patients admitted for detoxification between 1999 and 2008 in Barcelona, Spain. At admission, sociodemographic characteristics and a history of alcohol dependence and abuse of illegal drugs were obtained through clinical interviews and questionnaires. Medical comorbidity was assessed with the Cumulative Illness Rating Scale (Substance Abuse) (CIRS-SA). Dates and causes of death were obtained from clinical records and death registers. Survival was analyzed using Kaplan-Meier methods, and Cox regression models were used to analyze the risk factors for premature death. Median age of the patients (686 total, 79.7% men) was 43.5 years (interquartile range [IQR], 37.8 to 50.4), average alcohol consumption was 200 g/d (IQR, 120 to 280 g/d), and duration of alcohol use disorder was 18 years (IQR, 11 to 24). Medical comorbidity by CIRS-SA at admission showed that the organs/systems most affected were liver (99%), respiratory (86%), and cardiovascular (58%). After median follow-up of 3.1 years (IQR, 1.5 to 5.1), 78 (11.4%) patients died with a mortality rate of 3.28 × 100 person-years; according to Kaplan-Meier estimates, 50% (95% confidence interval [95% CI], 24 to 69%) of patients with severe medical comorbidity died in the first decade after treatment. In multivariate analysis, severe medical comorbidity (hazard ratio [HR], 5.5; 95% CI, 3.02 to 10.07) and being treated with methadone at admission (HR, 2.60; 95% CI, 1.50 to 4.51) were independent risk factors for premature death. Systematic assessment of alcohol-related organ damage is relevant for the identification and treatment of those at increased risk of death.
    Alcoholism Clinical and Experimental Research 01/2013; 37 Suppl 1(suppl 1):E221-7. DOI:10.1111/j.1530-0277.2012.01861.x · 3.21 Impact Factor
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    • "However, among the heavy drinkers, smokers tended to have even higher blood pressure than nonsmokers. Interestingly, though research has shown that light alcohol consumption has cardiovascular benefits despite the associated increases in blood pressure (Burger et al., 2004; Gordon & Doyle, 1986; Keil et al., 1993; Klatsky, 2004; Moreira et al., 1998) light-drinking smokers were found to have significantly higher blood pressure in comparison to light-drinking nonsmokers (Wakabayashi, 2008). Thus, there appears to be an additive increase in blood pressure from moderate alcohol consumption and smoking. "
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    ABSTRACT: The current study explored the relation between blood pressure and the Alcohol Use Disorders Identification Test (AUDIT) scores among cigarette smokers and their nonsmoking peers. When par-ticipants were assessed collectively, only a modest positive cor-relation between blood pressure and AUDIT score was observed. When assessed by smoking status, however, smokers demonstrated a significant relation between higher blood pressure and increased AUDIT scores. Findings from this study suggest that there is an additive increase in blood pressure when increasing levels of alco-hol use and related problems is combined with cigarette smoking. Screening and treatment implications are also discussed.
    Alcoholism Treatment Quarterly 04/2011; 29(2):123-131. DOI:10.1080/07347324.2011.557984
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